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Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective

Published on Jan 1, 2017in Oxidative Medicine and Cellular Longevity4.868
路 DOI :10.1155/2017/8214541
Jinfan Tian4
Estimated H-index: 4
,
Yingke Zhao2
Estimated H-index: 2
+ 3 AuthorsShuzheng Lyu4
Estimated H-index: 4
Abstract
Diabetic cardiomyopathy is one of the major complications among patients with diabetes mellitus. Diabetic cardiomyopathy (DCM) is featured by left ventricular hypertrophy, myocardial fibrosis, and damaged left ventricular systolic and diastolic functions. The pathophysiological mechanisms include metabolic-altered substrate metabolism, dysfunction of microvascular, renin-angiotensin-aldosterone system (RAAS) activation, oxidative stress, cardiomyocyte apoptosis, mitochondrial dysfunction, and impaired Ca2
  • References (107)
  • Citations (9)
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References107
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#1Shuqin Sun (Qingdao University)H-Index: 2
#2Shuo Yang (Qingdao University)H-Index: 2
Last. Yongjun Mao (Qingdao University)H-Index: 3
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Background Apoptosis plays a critical role in the progression of diabetic cardiomyopathy (DC). Astragalus polysaccharides (APS), an extract of astragalus membranaceus (AM), is an effective cardioprotectant. Currently, little is known about the detailed mechanisms underlying cardioprotective effects of APS. The aims of this study were to investigate the potential effects and mechanisms of APS on apoptosis employing a model of high glucose induction of apoptosis in H9C2 cells.
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#1Hedyieh Karbasforooshan (MUMS: Mashhad University of Medical Sciences)H-Index: 3
#2Gholamreza Karimi (MUMS: Mashhad University of Medical Sciences)H-Index: 23
Abstract The prevalence of diabetes mellitus (DM) has been increasing worldwide. Diabetic cardiomyopathy (DCP) is the major risk for diabetes associated morbidity and mortality. Hyperglycemia and hyperinsulinemia play an indispensable role in underlying mechanisms of DCP. They increase advanced glycation end products (AGEs) following a series of events leading to myocardial damage and cardiomyopathy which include oxidative stress, increased inflammation, fibrosis, hypertrophy and apoptosis. SIRT...
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We substantiated the role of peroxisome proliferator-activated receptor-纬 (PPAR-纬) activation in the protective effect of apigenin against the myocardial infarction (MI) in diabetic rats. Diabetes was induced by intraperitoneal administration of a single dose of streptozotocin (55 mg/kg). The study groups included diabetic rats receiving vehicle, apigenin (75 mg/kg/day, orally), GW9662 (1 mg/kg/day, intraperitoneally), and a combination of apigenin and GW9662 for 14 days. The MI was induced in a...
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#1Shih-Hsiang Lo (TCU: Tzu Chi University)H-Index: 5
#2Chao-Tien Hsu (ISU: I-Shou University)H-Index: 4
Last. Zhih-Cherng Chen (CNU: Chia Nan University of Pharmacy and Science)H-Index: 9
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Cryptotanshinone is an active principal ingredient isolated from Salvia miltiorrhiza (Danshen), a medicinal plant used in China to treat cardiac disorders. The objective of this study was to investigate the effect of cryptotanshinone on myocardial fibrosis in diabetic rats. In streptozotocin-induced type 1 diabetic model hyperglycemic rats (STZ-treated rats), fasting blood glucose levels and heart weight/body weight ratio were markedly increased but both were not modified by cryptotanshinone. Ad...
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#1Bin ZhangH-Index: 3
#2Qiang ShenH-Index: 2
Last. Xiaobo SunH-Index: 14
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Myricitrin Alleviates Oxidative Stress-induced Inflammation and Apoptosis and Protects Mice against Diabetic Cardiomyopathy
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#1Rujun Li (YZU: Yangzhou University)H-Index: 3
#2Kuiying Lu (YZU: Yangzhou University)H-Index: 1
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Abstract Triptolide is the predominant active component of the Chinese herb Tripterygium wilfordii Hook F (TwHF) that has been widely used to treat several chronic inflammatory diseases due to its immunosuppressive, anti-inflammatory, and anti-proliferative properties. In the present study, we elucidated the cardioprotective effects of triptolide against cardiac dysfunction and myocardial remodeling in chronic pressure-overloaded hearts. Furthermore, the potential mechanisms of triptolide were i...
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#1Xiong-Wei Xie (Nanjing Medical University)H-Index: 2
Abstract Diabetes combined with cardiomyopathy is considered as an essential complication, showing diastolic persistently and causing cardiac injury, which is linked to fibrosis progression and inflammation response. Fibrosis and inflammation response are two markers for cardiomyopathy. Liquiritigenin is a flavanone, isolated from Radix glycyrrhiza, which exhibits various biological properties, including anti-cancer and anti-inflammatory activities. Here, in our study, the protective effects and...
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#1Jin Li (Austrian Academy of Sciences)H-Index: 5
#2Tamara Casteels (Austrian Academy of Sciences)H-Index: 1
Last. Stefan Kubicek (Austrian Academy of Sciences)H-Index: 28
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Type 1 diabetes is characterized by the destruction of pancreatic 尾 cells, and generating new insulin-producing聽cells from other cell types is a major aim of regenerative medicine. One promising approach is transdifferentiation of developmentally related pancreatic cell types, including glucagon-producing 伪 cells. In a genetic model, loss of the master regulatory transcription factor Arx is sufficient to induce the conversion of 伪 cells to functional 尾-like cells. Here, we identify artemisinins ...
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#1Gurinder Bir Singh (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 5
#2Satish K. Raut (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 7
Last. Madhu Khullar (PGIMER: Post Graduate Institute of Medical Education and Research)H-Index: 26
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Mitogen-activated protein kinases (MAPKs) (ERK1/2, JNK, and p38) are upregulated in diabetic cardiomyopathy (DCM). Dual-specific phosphatase-1 (DUSP-1) has been reported to regulate the activity of MAPKs in cardiac hypertrophy; however, the role of DUSP-1 in regulating MAPKs activity in DCM is not known. MicroRNAs have been reported to regulate the expression of several genes in hypertrophied failing hearts. However, little is known about the microRNAs regulating DUSP-1 expression in diabetes-re...
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Sheng Mai San (SMS) has been proven to exhibit cardio-protective effects. This study aimed to explore the molecular mechanisms of SMS on hyperglycaemia (HG)-induced apoptosis in H9C2 cells. HG-induced H9C2 cells were established as the experimental model, and then treated with SMS at 25, 50, and 100鈥壩糶/mL. H9C2 cell viability and apoptosis were quantified using MTT and Annexin V-FITC assays, respectively. Furthermore, Bcl-2/Bax signalling pathway protein expression and Fas and FasL gene expressi...
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#1Bin Wu (HUST: Huazhong University of Science and Technology)
#2Xueyuan Huang (CSU: Central South University)H-Index: 1
Last. Shun Wang (HUST: Huazhong University of Science and Technology)H-Index: 1
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Diabetic cardiomyopathy is characterized by diabetes鈥恑nduced myocardial abnormalities, accompanied by inflammatory response and alterations in inflammation鈥恟elated signalling pathways. Kirenol, isolated from Herba Siegesbeckiae, has potent anti鈥恑nflammatory properties. In this study, we aimed to investigate the cardioprotective effect of kirenol against DCM and underlying the potential mechanisms in a type 2 diabetes mellitus model. Kirenol treatment significantly decreased high glucose鈥恑nduced ...
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#1Shi-Qiang Wang (Hunan University of Technology)H-Index: 1
#2Dan Li (Hunan University of Technology)H-Index: 1
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Exercise has an effect on the reduction of myocardial fibrosis in diabetic rats as previously reported, in which oxidative stress and the TGF-尾1/Smad signaling pathway may play key roles. There is little direct experimental evidence that exercise alleviates myocardial fibrosis in type 2 diabetes mellitus (T2DM). Here we established a type 2 diabetic model by using streptozotocin and a high-fat diet. Rats were divided into groups of normal control (NC), T2DM and T2DM plus exercise (T2DME). The T2...
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#1Xuefei Dong (SDU: Shandong University)H-Index: 1
#2Shiran Yu (SDU: Shandong University)H-Index: 1
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Excessive activation of the renin-angiotensin system (RAS) in diabetic cardiomyopathy (DCM) provokes a series of structural and functional abnormalities, and causes ventricular remodeling and heart failure in diabetes. (Pro)renin receptor (PRR) is a component of the RAS and has been reported to be up-regulated in some cardiovascular diseases. Furthermore, PRR blockade in some cardiovascular diseases, such as myocardial infarction and hypertension, has been demonstrated to reverse their pathogene...
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Abstract The present study aimed to investigate the protective effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on diabetic cardiomyopathy (DCM)-associated apoptosis and if this effect is mediated via modulating the activity of the survival kinases; AMP-activated protein kinase (AMPK) and Akt & the apoptotic kinases; glycogen synthase kinase-3 尾 (GSK-3尾) and p38 mitogen-activated protein kinase (p38MAPK). Diabetes was induced by a single intraperitoneal injection of streptozotocin (55鈥...
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Diabetes-associated cardiac fibrosis is a severe cardiovascular complication. Momordicine I, a bioactive triterpenoid isolated from bitter melon, has been demonstrated to have antidiabetic properties. This study investigated the effects of momordicine I on high-glucose-induced cardiac fibroblast activation. Rat cardiac fibroblasts were cultured in a high-glucose (25鈥塵M) medium in the absence or presence of momordicine I, and the changes in collagen synthesis, transforming growth factor-尾1 (TGF-尾...
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Yacon (Smallanthus sonchifolius) is a native Andean plant rich in phenolic compounds, and its effects on dysmetabolism and cardiomyopathy in diabetic rats was evaluated. The rats (10/group) were allocated as follows: C, controls; C
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