Application of ¹⁹F NMR Spectroscopy for Content Determination of Fluorinated Pharmaceuticals

A simple, rapid, and selective quantitative nuclear magnetic resonance spectroscopic method was evaluated for the determination of the content of fluorinated pharmaceuticals. 19 F NMR spectra were either obtained in dimethylsulfoxide- d 6 or aqueous buffer, using trifluoroacetic acid as internal standard. Quantification of 13 fluorine-containing pharmaceuticals spanning various pharmacological classes was accomplished using the proposed method....