Original paper
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
Abstract
The spontaneous deamination of cytosine is a major source of transitions from C•G to T•A base pairs, which account for half of known pathogenic point mutations in humans. The ability to efficiently convert targeted A•T base pairs to G•C could therefore advance the study and treatment of genetic diseases. The deamination of adenine yields inosine, which is treated as guanine by polymerases, but no enzymes are known to deaminate adenine in DNA....
Paper Details
Title
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
Published Date
Nov 1, 2017
Journal
Volume
551
Issue
7681
Pages
464 - 471
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Notes
History