Match!

Obesity as a Disease

Published on Jan 1, 2018in Medical Clinics of North America2.716
· DOI :10.1016/j.mcna.2017.08.004
Jagriti Upadhyay10
Estimated H-index: 10
(BMC: Boston Medical Center),
Olivia M. Farr20
Estimated H-index: 20
(BIDMC: Beth Israel Deaconess Medical Center)
+ 2 AuthorsChristos S. Mantzoros106
Estimated H-index: 106
(BIDMC: Beth Israel Deaconess Medical Center)
Abstract
  • References (186)
  • Citations (42)
📖 Papers frequently viewed together
2 Citations
2014
1 Author (Maren Ekeland)
2003
12 Authors (James Shepherd, ..., J Foxton)
78% of Scinapse members use related papers. After signing in, all features are FREE.
References186
Newest
#1Weerapat Kositanurit (Chula: Chulalongkorn University)H-Index: 1
#2Dittapol Muntham (Rajamangala University of Technology)H-Index: 1
Last. Naricha Chirakalwasan (Chula: Chulalongkorn University)H-Index: 7
view all 4 authors...
Purpose Our goal in this study is to determine the prevalence and associated factors of obstructive sleep apnea (OSA) in morbidly obese patients undergoing bariatric surgery.
5 CitationsSource
#1George A. Bray (LSU: Louisiana State University)H-Index: 117
#2K.K. Kim (KU: Korea University)H-Index: 1
Last. John Wilding (University of Liverpool)H-Index: 58
view all 3 authors...
Summary This paper considers the argument for obesity as a chronic relapsing disease process. Obesity is viewed from an epidemiological model, with an agent affecting the host and producing disease. Food is the primary agent, particularly foods that are high in energy density such as fat, or in sugar-sweetened beverages. An abundance of food, low physical activity and several other environmental factors interact with the genetic susceptibility of the host to produce positive energy balance. The ...
108 CitationsSource
#1Thea BjørnlandH-Index: 2
#2Mette LangaasH-Index: 18
Last. I. L. MostadH-Index: 9
view all 4 authors...
© 2017 Bjornland et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
7 CitationsSource
#1Geoffrey C. Kabat (Yeshiva University)H-Index: 49
#2Wendy Yi Ying Wu (NTU: National Taiwan University)H-Index: 7
Last. TomRohan (Yeshiva University)H-Index: 74
view all 11 authors...
Metabolic phenotypes of obesity: frequency, correlates and change over time in a cohort of postmenopausal women
14 CitationsSource
#1Dinko SusicH-Index: 28
#2Jasmina Varagic (Wake Forest University)H-Index: 30
The prevalence of obesity-related hypertension is high worldwide and has become a major health issue. The mechanisms by which obesity relates to hypertensive disease are still under intense research scrutiny, and include altered hemodynamics, impaired sodium homeostasis, renal dysfunction, autonomic nervous system imbalance, endocrine alterations, oxidative stress and inflammation, and vascular injury. Most of these contributing factors interact with each other at multiple levels. Thus, as a mul...
10 CitationsSource
#1Valentine Yanchou Njike (Yale University)H-Index: 24
#2Teresa M. SmithH-Index: 8
Last. Amy L. YarochH-Index: 34
view all 7 authors...
16 CitationsSource
#1Olivia M. Farr (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 20
#2Michael A. Tsoukas (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 9
Last. Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 106
view all 7 authors...
Abstract Background GLP-1 agonists, including liraglutide, have emerged as effective therapies for type 2 diabetes (DM) and obesity. Here, we attempted to delineate how liraglutide, at doses approved for DM, may impact circulating hormones influencing energy homeostasis in diabetics. Basic Procedures Using a randomized, placebo-controlled, double-blind, cross-over trial of 20 patients with type 2 diabetes, we examined the effects of liraglutide as compared to placebo on fasting levels of circula...
28 CitationsSource
#1Olivia M. Farr (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 20
#2Chiang-shan R. Li (Yale University)H-Index: 43
Last. Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 106
view all 3 authors...
Appetite and body weight regulation are controlled by the central nervous system (CNS) in a rather complicated manner. The human brain plays a central role in integrating internal and external inputs to modulate energy homeostasis. Although homeostatic control by the hypothalamus is currently considered to be primarily responsible for controlling appetite, most of the available evidence derives from experiments in rodents, and the role of this system in regulating appetite in states of hunger/st...
36 CitationsSource
#1Scott Kahan (Johns Hopkins University)H-Index: 11
#2Tracy Zvenyach (UMD: University of Maryland, College Park)H-Index: 1
The recognition of obesity as a chronic disease is increasing. However, there is variable acknowledgment of it as a disease in health policies across the USA. The objective of this review is to describe how obesity meets the definition of a disease, explain its interpretation in current health policies, and explore implications for obesity in future health policy adoption and development. Perspectives are presented from scientific evidence, clinical practice, and health policy areas including Me...
10 CitationsSource
#1Lucy CookeH-Index: 30
#2Clare H. LlewellynH-Index: 25
Obesity has reached epidemic proportions and research into its prevention is increasingly focusing on the earliest stages of life. Avidity of appetite has been linked to a higher risk of obesity, but studies in infancy were scarce. The Gemini twin cohort was established to investigate genetic and environmental determinants of weight trajectories in early childhood with a focus on appetite and the home environment. Gemini families have been supplying questionnaire data at regular intervals, start...
2 CitationsSource
Cited By42
Newest
#1David C. Nieman (ASU: Appalachian State University)H-Index: 72
Acute and chronic respiratory illnesses cause widespread morbidity and mortality, and this class of illness now includes the novel coronavirus severe acute respiratory syndrome (SARS-CoV-2) that is causing Coronavirus Disease 2019 (COVID-19). The world is experiencing a major demographic shift towards an older, obese, and physically inactive populace. Risk factor assessments based on pandemic data indicate that those at higher risk for severe illness from COVID-19 include older males, and people...
Source
#1Diana CookeH-Index: 3
Last. Gene P. AblesH-Index: 9
view all 6 authors...
OBJECTIVE: Identifying novel approaches to combat obesity is important to improve health span. It was hypothesized that methionine restriction (MR) will induce weight loss in obese mice by reducing adipose tissue mass caused by increased energy expenditure and reprogramming of adipose tissue homeostasis. The roles of adiponectin (ADIPOQ) and fibroblast growth factor 21 (FGF21) during weight loss in MR mice were also tested. METHODS: Diet-induced obese (DIO) male C57BL/6J (wild type), Adipoq-defi...
Source
#1Maria-Dolores Santos (University of Lleida)
#2Miquel ButiH-Index: 2
Last. Marta Bueno (University of Lleida)H-Index: 1
view all 11 authors...
Introduction: Paired cohort investigations assessing the evolution of anthropometric indices are scarce. Here we assessed the 10-year evolution of BMI, total body fat, and lean body mass in 50,019 participants aged 18 to 90 years at the time of first assessment. Material and Methods: A retrospective cohort study using an electronic database that contains anonymized, longitudinal data from Primary Care medical records covering the 2007–2008 and 2017–2018 periods. Total body fat was estimated usin...
Source
Source
#1Qin Tang (Sichuan University)H-Index: 1
#2Yong Gao (Guangzhou University of Chinese Medicine)
Last. Rui Li (Sichuan University)H-Index: 5
view all 19 authors...
Abstract Objective Sirt6 is an essential regulator of energy metabolism in multiple peripheral tissues. However, the direct role of Sirt6 in the hypothalamus, and specifically pro-opiomelanocortin (POMC) neurons, controlling energy balance has not been established. Here, we aimed to determine the role of Sirt6 in hypothalamic POMC neurons in the regulation of energy balance and the underlying mechanisms. Methods For overexpression studies, the hypothalamic arcuate nucleus (ARC) of diet-induced o...
Source
#1Camila Ferreira de Oliveira (UFG: Universidade Federal de Goiás)
view all 9 authors...
Source
#1Alyssa D. Cordero (AU: American University)
#2Evan C. CallihanH-Index: 1
Last. John R. BrachtH-Index: 10
view all 6 authors...
Expansion of subcutaneous adipose tissue by differentiation of new adipocytes has been linked to improvements in metabolic health. However, an expandability limit has been observed wherein new adipocytes cannot be produced, the existing adipocytes become enlarged (hypertrophic) and lipids spill over into ectopic sites. Inappropriate ectopic storage of these surplus lipids in liver, muscle, and visceral depots has been linked with metabolic dysfunction. Here we show that Neuregulin-1 (NRG1) serve...
Source
Last. Angkoon AnuwongH-Index: 12
view all 5 authors...
Transoral endoscopic thyroidectomy vestibular approach (TOETVA) has been employed as one surgical modality approach for multiple thyroid and parathyroid disease conditions with good results. The indication and patient selection is extended by the experience of surgeon, especially when considering including obesity patient and reoperation. With such special consideration, the surgeon must know the impact of body composition on the operation, consequences of previous neck surgery, and anesthetic c...
Source
#1Alexander Egeberg (Gentofte Hospital)H-Index: 19
#2Paolo Gisondi (University of Verona)H-Index: 37
Last. Ulrich MrowietzH-Index: 56
view all 5 authors...
Alterations in the innate and adaptive immunity underpin psoriasis pathophysiology, with the Th17 cells subset now recognized as the fundamental cells in the key controlling pathway involved in its pathogenesis. Since psoriasis is a systemic disease with important comorbidity, further knowledge on the interleukin (IL)-23/Th17 axis led to the hypothesis that there may be shared pathogenic pathways between primary skin disease and comorbidity. Psoriasis has been identified as a risk factor for car...
2 CitationsSource
#1Andrea G. Izquierdo (Epigenomics AG)H-Index: 1
#2Marcos C. Carreira (Ciber)H-Index: 14
Last. Ana B. Crujeiras (Epigenomics AG)H-Index: 29
view all 9 authors...
The epidemiological evidence regarding the association of obesity with liver disease and possibly hepatocellular carcinoma highlights the need for investigations of whether obesity itself could induce the differential expression of genes commonly associated with the initial phase of liver tumorigenesis, and whether such phenomenon could be reversed after a weight loss intervention. In this study, obese Zucker rats were found to have dysregulated cell proliferation, antioxidative defenses, and tu...
Source