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Christos S. Mantzoros
Harvard University
687Publications
106H-index
40.9kCitations
Publications 693
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Abstract Objective: Preeclampsia is a common disorder of pregnancy, causing significant morbidity and mortality for mothers and infants. Several molecules, including glycosylated fibronectin (GlyFn...
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#1Natia Peradze (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 2
#2Olivia M. Farr (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 20
Last.Christos S. Mantzoros (Harvard University)H-Index: 106
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Long-term treatment with up to 1.8 mg liraglutide improves cardiovascular and all-cause mortality in patients with type 2 diabetes at high risk for cardiovascular disease (CVD) and is currently under investigation in subjects without diabetes. Aim of our study was to investigate whether high dose (3 mg) short-term (5 weeks) treatment with liraglutide in obese patients with no overt type 2 diabetes affects metabolites, lipid and lipoprotein profile and components of activin–follistatin axis in ca...
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ATPase inhibitory factor 1 (IF1) is an ATP synthase–interacting protein that suppresses the hydrolysis activity of ATP synthase. In this study, we observed that the expression of IF1 was up-regulat...
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#1Nikolaos Perakakis (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 9
#2Alexander Kokkinos (UoA: National and Kapodistrian University of Athens)H-Index: 15
Last.Christos S. Mantzoros (Harvard University)H-Index: 106
view all 9 authors...
Abstract Aims Bariatric surgery leads to profound and sustainable weight loss. Gastrointestinal hormones are involved in energy and glucose homeostasis, thus postoperative changes of their circulating levels may be mediating future weight loss. To investigate how the circulating concentrations of gastrointestinal hormones change in response to the most common types of bariatric operation and whether these changes can predict future weight loss. Materials and Methods We measured circulating GLP-1...
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Abstract Background Non-alcoholic fatty liver disease (NAFLD) affects 25–30% of the general population and is characterized by the presence of non-alcoholic fatty liver (NAFL) that can progress to non-alcoholic steatohepatitis (NASH), liver fibrosis and cirrhosis leading to hepatocellular carcinoma. To date, liver biopsy is the gold standard for the diagnosis of NASH and for staging liver fibrosis. This study aimed to train models for the non-invasive diagnosis of NASH and liver fibrosis based o...
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#1Alexander Kokkinos (UoA: National and Kapodistrian University of Athens)H-Index: 15
#2Dimitrios Tsilingiris (UoA: National and Kapodistrian University of Athens)H-Index: 1
Last.Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 106
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Abstract Bariatric surgery is currently the most effective therapeutic modality through which sustained beneficial effects on weight loss and metabolic improvement are achieved. During recent years, indications for bariatric surgery have been expanded to include cases of poorly controlled type 2 (T2DM) diabetes mellitus in lesser extremes of body weight. A spectrum of the beneficial effects of surgery is attributed to robust changes of postprandial gut peptide responses that are observed post op...
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#1Bridget DiPrisco (Boston Children's Hospital)H-Index: 1
#2Ajay KumarH-Index: 82
Last.Christos S. Mantzoros (Harvard University)H-Index: 106
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Abstract Background A newborn's birth weight for gestational age provides important insights into his or her fetal growth and well-being. While the underlying mechanisms regulating fetal growth remain to be fully elucidated, the IGF-axis plays an important role. Some components of this axis have been well-characterized in umbilical cord blood, but others have not yet been studied. We measured the proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and -5), and the established...
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