Original paper
MKK6 controls T3-mediated browning of white adipose tissue
Abstract
Increasing the thermogenic capacity of adipose tissue to enhance organismal energy expenditure is considered a promising therapeutic strategy to combat obesity. Here, we report that expression of the p38 MAPK activator MKK6 is elevated in white adipose tissue of obese individuals. Using knockout animals and shRNA, we show that Mkk6 deletion increases energy expenditure and thermogenic capacity of white adipose tissue, protecting mice against...
Paper Details
Title
MKK6 controls T3-mediated browning of white adipose tissue
Published Date
Oct 11, 2017
Journal
Volume
8
Issue
1
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Notes
History