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CRISPR Becomes Clearer

Published on Sep 1, 2017in Hastings Center Report1.728
· DOI :10.1002/hast.762
Andrew W. Torrance5
Estimated H-index: 5
Abstract
  • References (5)
  • Citations (0)
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References5
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#1Hong Ma (Oregon National Primate Research Center)H-Index: 27
#2Nuria Marti-Gutierrez (OHSU: Oregon Health & Science University)H-Index: 1
Last. Shoukhrat MitalipovH-Index: 36
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CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
328 CitationsSource
125 CitationsSource
#1Puping Liang (SYSU: Sun Yat-sen University)H-Index: 8
#2Yanwen Xu (SYSU: Sun Yat-sen University)H-Index: 15
Last. Junjiu Huang (SYSU: Sun Yat-sen University)H-Index: 19
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Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious knowledge gap remains in our understanding of DNA repair mechanisms in human early embryos, and in the efficiency and potential off-target effects of using technologies such as CRISP...
505 CitationsSource
#1David Baltimore (California Institute of Technology)H-Index: 176
#2Paul Berg (Stanford University)H-Index: 74
Last. K.R. Yamamoto (University of California, Berkeley)H-Index: 2
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A framework for open discourse on the use of CRISPR-Cas9 technology to manipulate the human genome is urgently needed
292 CitationsSource
#1A.C. Hendriks (UvA: University of Amsterdam)H-Index: 5
501 CitationsSource
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