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Published on Apr 3, 2015in Science 41.06
David Baltimore169
Estimated H-index: 169
(California Institute of Technology),
Paul Berg70
Estimated H-index: 70
(Stanford University)
+ 15 AuthorsMarsha Fenner1
Estimated H-index: 1
(University of California, Berkeley)
A framework for open discourse on the use of CRISPR-Cas9 technology to manipulate the human genome is urgently needed
258 Citations Source Cite
Published on May 1, 2015in Protein & Cell 6.23
Puping Liang6
Estimated H-index: 6
(Sun Yat-sen University),
Y. Xu5
Estimated H-index: 5
(Sun Yat-sen University)
+ 13 AuthorsYujing Li5
Estimated H-index: 5
(Sun Yat-sen University)
Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious knowledge gap remains in our understanding of DNA repair mechanisms in human early embryos, and in the efficiency and potential off-target effects of using technologies such as CRISP...
417 Citations Source Cite
Published on Nov 15, 2016in Nature 41.58
David Cyranoski31
Estimated H-index: 31
105 Citations Source Cite
Published on Aug 1, 2017in Nature 41.58
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(Oregon Health & Science University)
+ 28 AuthorsRiffat Ahmed10
Estimated H-index: 10
(Oregon Health & Science University)
Genome editing could be applied to correct disease-causing mutations in human embryos, but concerns about efficacy and safety are paramount. Shoukhrat Mitalipov and colleagues use CRISPRCas9 to correct a heritable cardiomyopathy mutation in human embryos. By optimizing the experimental conditions, the authors show very reduced mosaicism, and report that for this heterozygous mutation, CRISPRCas9-induced breaks seem to be preferentially repaired using the wild-type allele as a template in human e...
238 Citations Source Cite
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