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Published on Aug 1, 2017in Nature 41.58
Hong Ma27
Estimated H-index: 27
(Oregon National Primate Research Center),
Nuria Marti-Gutierrez1
Estimated H-index: 1
(Oregon Health & Science University)
+ 28 AuthorsRiffat Ahmed10
Estimated H-index: 10
(Oregon Health & Science University)
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
259 Citations Source Cite
Published on Nov 15, 2016in Nature 41.58
David Cyranoski31
Estimated H-index: 31
111 Citations Source Cite
Published on May 1, 2015in Protein & Cell 6.23
Puping Liang7
Estimated H-index: 7
(Sun Yat-sen University),
Yanwen Xu14
Estimated H-index: 14
(Sun Yat-sen University)
+ 13 AuthorsYujing Li10
Estimated H-index: 10
(Sun Yat-sen University)
Genome editing tools such as the clustered regularly interspaced short palindromic repeat (CRISPR)-associated system (Cas) have been widely used to modify genes in model systems including animal zygotes and human cells, and hold tremendous promise for both basic research and clinical applications. To date, a serious knowledge gap remains in our understanding of DNA repair mechanisms in human early embryos, and in the efficiency and potential off-target effects of using technologies such as CRISP...
458 Citations Source Cite
Published on Apr 3, 2015in Science 41.06
David Baltimore173
Estimated H-index: 173
(California Institute of Technology),
Paul Berg73
Estimated H-index: 73
(Stanford University)
+ 15 AuthorsMarsha Fenner1
Estimated H-index: 1
(University of California, Berkeley)
A framework for open discourse on the use of CRISPR-Cas9 technology to manipulate the human genome is urgently needed
273 Citations Source Cite
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