Original paper
Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer
Abstract
The presence of tumor-infiltrating lymphocytes in triple-negative breast cancers is correlated with improved outcomes. Ras/MAPK pathway activation is associated with significantly lower levels of tumor-infiltrating lymphocytes in triple-negative breast cancers and while MEK inhibition can promote recruitment of tumor-infiltrating lymphocytes to the tumor, here we show that MEK inhibition adversely affects early onset T-cell effector function. We...
Paper Details
Title
Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer
Published Date
Sep 19, 2017
Journal
Volume
8
Issue
1
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Notes
History