Original paper

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

Volume: 8, Issue: 1
Published: Sep 19, 2017
Abstract
The presence of tumor-infiltrating lymphocytes in triple-negative breast cancers is correlated with improved outcomes. Ras/MAPK pathway activation is associated with significantly lower levels of tumor-infiltrating lymphocytes in triple-negative breast cancers and while MEK inhibition can promote recruitment of tumor-infiltrating lymphocytes to the tumor, here we show that MEK inhibition adversely affects early onset T-cell effector function. We...
Paper Details
Title
Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer
Published Date
Sep 19, 2017
Volume
8
Issue
1
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.