Original paper

BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination

Volume: 8, Issue: 1
Published: Sep 13, 2017
Abstract
Mutations in the tumor suppressor BRCA2 predominantly predispose to breast cancer. Paradoxically, while loss of BRCA2 promotes tumor formation, it also causes cell lethality, although how lethality is triggered is unclear. Here, we generate BRCA2 conditional non-transformed human mammary epithelial cell lines using CRISPR-Cas9. Cells are inviable upon BRCA2 loss, which leads to replication stress associated with under replication, causing...
Paper Details
Title
BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination
Published Date
Sep 13, 2017
Volume
8
Issue
1
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