Targeting aspirin resistance with nutraceuticals: a possible strategy for reducing cardiovascular morbidity and mortality

The failure of daily aspirin therapy to achieve an adequate or ‘normal’ suppression of platelet aggregation, as assessed ex vivo, is known as ‘aspirin resistance’.1 2 A substantial fraction of patients classified as aspirin-resistant are in fact poorly compliant.3 In other cases, an increase in platelet turnover, often seen in association with systemic inflammation, as found in smokers and patients with diabetes, may render a once-daily...