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James H. O'Keefe
University of Missouri–Kansas City
373Publications
52H-index
12.2kCitations
Publications 373
Newest
Published on Dec 1, 2018in Trends in Cardiovascular Medicine 4.60
Carl J. Lavie82
Estimated H-index: 82
,
James J. DiNicolantonio24
Estimated H-index: 24
,
James H. O'Keefe52
Estimated H-index: 52
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Published on Jun 1, 2019
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Published on Mar 4, 2019in Journal of Dietary Supplements
Mark F. McCarty25
Estimated H-index: 25
,
James H. O'Keefe52
Estimated H-index: 52
(UMKC: University of Missouri–Kansas City),
James J. DiNicolantonio24
Estimated H-index: 24
ABSTRACTAlthough clinical trials with glucosamine in osteoarthritis have yielded mixed results, leading to doubts about its efficacy, the utility of glucosamine for preventing joint destruction and inflammation is well documented in rodent models of arthritis, including models of spontaneous osteoarthritis. The benefit of oral glucosamine in adjuvant arthritis is markedly dose dependent, likely reflecting a modulation of tissue levels of UDP-N-acetylglucosamine that in turn influences mucopolysa...
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Published on Mar 1, 2019in Journal of the American College of Cardiology 16.83
Zafar Ali , Ibrahim Saeed5
Estimated H-index: 5
+ 5 AuthorsKevin A. Bybee13
Estimated H-index: 13
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Published on Mar 1, 2019
James J DiNicolantonio5
Estimated H-index: 5
,
Mark F. McCarty25
Estimated H-index: 25
,
James H. O'Keefe52
Estimated H-index: 52
Gilbert syndrome (GS) is characterised by a lifelong genetically determined elevation of plasma unconjugated bilirubin levels.1 This typically entails decreased hepatic expression of the enzyme that conjugates free bilirubin to glucuronic acid, uridine-diphosphoglucuronate glucuronosyltransferase 1A1 (UGT1A1); this decreased activity reflects homozygosity for variant alleles in which promoter mutations decrease but do not eliminate transcription. In addition, genetic upregulation of bilirubin pr...
1 Citations Source Cite
Published on Feb 1, 2019
James J DiNicolantonio5
Estimated H-index: 5
,
Mark F. McCarty25
Estimated H-index: 25
,
James H. O'Keefe52
Estimated H-index: 52
(UMKC: University of Missouri–Kansas City)
To date, at least five prospective cohort studies have concluded that increased plasma levels of trimethylamine N-oxide (TMAO) predict increased risk for major adverse cardiovascular (CV) events in patients with pre-existing coronary heart disease.1–5 Moreover, though some epidemiology does not support a connection between plasma TMAO and CV risk,6 7 a recent meta-analysis of 11 prospective cohort studies concludes that higher plasma TMAO correlates with a 23% increase in risk for CV events (HR ...
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Published on Dec 1, 2018
Peter Schnohr64
Estimated H-index: 64
(Frederiksberg Hospital),
James H. O'Keefe52
Estimated H-index: 52
(MU: University of Missouri)
+ 4 AuthorsJacob Louis Marott26
Estimated H-index: 26
(Frederiksberg Hospital)
Abstract Objective To evaluate the differential improvements in life expectancy associated with participation in various sports. Patients and Methods The Copenhagen City Heart Study (CCHS) is a prospective population study that included detailed questionnaires regarding participation in different types of sports and leisure-time physical activity. The 8577 participants were followed for up to 25 years for all-cause mortality from their examination between October 10, 1991, and September 16, 1994...
3 Citations Source Cite
Published on Nov 1, 2018
James J DiNicolantonio5
Estimated H-index: 5
,
James H. O'Keefe52
Estimated H-index: 52
The consumption of seed oils high in the omega-6 polyunsaturated fat (PUFA) linoleic acid (LA) contributes to low-grade inflammation, oxidative stress, endothelial dysfunction and atherosclerosis.1 Moreover, dietary LA significantly increases cyclooxygenase-2 (COX-2) expression in the aorta,2 converting arachidonic acid (AA) to proinflammatory eicosanoids. This may explain why increasing LA intake can actually lower AA levels due to an increased breakdown into harmful proinflammatory metabolites...
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