Original paper
Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways
Abstract
Mitochondria are dynamic organelles that undergo fusion and fission events. Mitochondrial dynamics are required for mitochondrial viability and for responses to changes in bioenergetic status. Here we describe an insulin-signaling and SCFLIN-23-regulated pathway that controls mitochondrial fusion in Caenorhabditis elegans by repressing the expression of the mitochondrial proteases SPG-7 and PPGN-1. This pathway is required for mitochondrial...
Paper Details
Title
Increased mitochondrial fusion allows the survival of older animals in diverse C. elegans longevity pathways
Published Date
Aug 3, 2017
Journal
Volume
8
Issue
1
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Notes
History