Original paper
Skin Delivery of Hydrophilic Biomacromolecules Using Marine Sponge Spicules
Abstract
We report the development of sponge Haliclona sp. spicules, referred to as SHS, and its topical application in skin delivery of hydrophilic biomacromolecules, a series of fluorescein isothiocyanate-dextrans (FDs). SHS are silicious oxeas which are sharp-edged and rod-shaped (∼120 μm in length and ∼7 μm in diameter). SHS can physically disrupt skin in a dose-dependent manner and retain within the skin over at least 72 h, which allows sustained...
Paper Details
Title
Skin Delivery of Hydrophilic Biomacromolecules Using Marine Sponge Spicules
Published Date
Aug 18, 2017
Journal
Volume
14
Issue
9
Pages
3188 - 3200
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Notes
History