Original paper
Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function
Abstract
Coordinated cardiomyocyte growth, differentiation, and morphogenesis are essential for heart formation. We demonstrate that the bHLH transcription factors Hand1 and Hand2 play critical regulatory roles for left ventricle (LV) cardiomyocyte proliferation and morphogenesis. Using an LV-specific Cre allele (Hand1LV-Cre), we ablate Hand1-lineage cardiomyocytes, revealing that DTA-mediated cardiomyocyte death results in a hypoplastic LV by E10.5....
Paper Details
Title
Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function
Published Date
Jul 21, 2017
Journal
Volume
13
Issue
7
Pages
e1006922 - e1006922
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Notes
History