Switchable Target-Responsive 3D DNA Hydrogels As a Signal Amplification Strategy Combining with SERS Technique for Ultrasensitive Detection of miRNA 155

Usually, SERS technology requires labeling of the Raman reporter to obtain characteristic spectra for detection of biological samples. However, the number of labeled Raman reporters is often limited, resulting in the restricted improvement for sensitivity of SERS biosensor. In this work, switchable target-responsive 3D DNA hydrogels were introduced to precisely control trapping and release of Raman reporter toluidine blue (TB), which not only...