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Analytical Chemistry
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The use of a low aerosol dispersion ablation chamber within a LA-ICP-MS set up allows for high-resolution, high-speed imaging of the distribution of elements within a sample. Here we show how this enhanced capability creates new analytical problems and solutions. We report the distribution of platinum at the cellular level in non-small cell lung cancer (NSCLC) explant models after treatment with clinically relevant doses of cisplatin. This revealed for the first time a correlation between the pl...
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The HAAs are generally considered as environmental contaminants and are suspected to pose major public health concern. The inductively coupled plasma mass spectrometry (ICPMS) has been improved by coupling with the tandem mass spectrometry technology (ICPMS/MS), enabling ultra-trace determination of heteroatoms. There have been few reports about the determination of chlorine-containing analytes by HPLC-ICPMS/MS, but none about utilizing this technique for the speciation analysis of organic halog...
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Salt formation is a well-established method to increase the solubility of ionizable drug candidates. However, the possible conversion of salt to its original form of free acid or base - disproportionation - can have a drastic effect on solubility and consequently bioavailability of a drug. Therefore, during the salt selection process, salt dissolution behavior should be well understood. Improved understanding could be achieved by a method that enables simultaneous screening of small sample amoun...
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#1Lingling ZhangH-Index: 2
#2Rui HaoH-Index: 1
Last. Jixiang FangH-Index: 27
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How to fabricate Au nanostructures conveniently on micro/nanostructured arrays surface with low cost has become a crucial and urgent challenge. In this study, we demonstrate hierarchical flowerlike...
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#1Rui ZhuH-Index: 8
#2Yifan HuangH-Index: 6
Last. Yehia MechrefH-Index: 50
view all 5 authors...
Protein glycosylation is involved in many biological processes and physiological functions. Despite the recent advances in LC-MS/MS methodologies, the profiling of site-specific glycosylation is one of the major analytical challenges of glycoprotein analysis. Herein, we first reported the separation of glycopeptide isomers on porous graphitic carbon (PGC) LC was significantly improved by elevating the separation temperature under basic mobile phases. These findings permitted the isomeric separat...
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#1Seung-Woo SonH-Index: 3
#2Sungjune KimH-Index: 1
Last. Sunghwan KimH-Index: 31
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In this study, the reproducibility of crude oil analyzed with (+) atmospheric pressure photo ionization ultrahigh resolution mass spectrometry was evaluated. Three sets of data were obtained at an interval of approximately a month for a span of three months. For each monthly dataset, four oil samples were analyzed with four replicates in one day. The obtained 48 spectra were processed to examine the reproducibility of the class, double bond equivalence (DBE), and individual peak distributions. T...
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#1Bingyuan GuoH-Index: 4
#2Peng SongH-Index: 1
Last. Hai-Chen WuH-Index: 19
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Both vascular endothelial growth factor (VEGF) and matrix metallopeptidase-9 (MMP-9) are key biomarkers in tumor angiogenesis. Determination of the overexpression of the two biomarkers would provide valuable information of the progression of tumor growth and metastasis, but their simultaneous quantification by a single probe is unprecedented. Here, we develop a triplex DNA-based nanoprobe for simultaneously quantifying VEGF and MMP-9 using α-hemolysin nanopore. A DNA aptamer is used as the tripl...
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#1Huanhuan XingH-Index: 6
#2Chao PengH-Index: 1
Last. Erkang WangH-Index: 70
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Designing the catalytic interface that preferentially attracts reactants is highly desirable for amplifying chemiluminescence (CL) emission. Herein, to boost the generation of reactive oxygen species (ROS) from dissolved O2 molecule, flower-like cobalt hydroxide (f-Co(OH)2) based catalytic interface with hierarchical and porous architecture were in-situ created in the co-existence of BSA and Co2+. Benefiting from the oxidase-like catalysis capability and the unique microstructure of f-Co(OH)2, R...
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Amyloid β-peptide oligomer (AβO) is widely acknowledged as the promising biomarker for the diagnosis of Alzheimer’s disease (AD). In this work, we designed a three-dimensional (3D) DNA walker nanop...
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#1Lili CongH-Index: 1
#2Yijia GengH-Index: 4
Last. Shuping XuH-Index: 26
view all 9 authors...
A high-throughput single-cell analytical technique based on the microdroplet array integrated with the plasmon-enhanced four-wave mixing (PE-FWM) imaging was developed, which is appliable for the highly sensitive and automatic assessment of the surface receptors of cells. The metal nanoprobes were prepared by simply decorating metal nanoparticles with capturing molecules (antibody or molecules with surface identification function). Owing to the multi-frequency selection of lasers via resonating ...
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Analytical chemistry
Mass spectrometry
Inorganic chemistry
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