MutSβ abundance and Msh3 ATP hydrolysis activity are important drivers of CTG•CAG repeat expansions
Abstract
CTG•CAG repeat expansions cause at least twelve inherited neurological diseases. Expansions require the presence, not the absence, of the mismatch repair protein MutSβ (Msh2-Msh3 heterodimer). To evaluate properties of MutSβ that drive expansions, previous studies have tested under-expression, ATPase function or polymorphic variants of Msh2 and Msh3, but in disparate experimental systems. Additionally, some variants destabilize MutSβ,...
Paper Details
Title
MutSβ abundance and Msh3 ATP hydrolysis activity are important drivers of CTG•CAG repeat expansions
Published Date
Jul 21, 2017
Journal
Volume
45
Issue
17
Pages
10068 - 10078
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