Drug-loaded pH-responsive polymeric micelles: Simulations and experiments of micelle formation, drug loading and drug release
Abstract
pH-responsive drug nanocarriers are widely applied for cancer treatment. However, the mechanistic details of drug loading and drug release from these micelles are unknown. Here, we reveal the mechanistic details of micelle formation, drug loading and drug release from pH-responsive polymeric micelles using computer simulations and experiments. A triblock amphiphilic copolymer, methoxy-poly(ethylene glycol) 2000-poly(2-(N,N-diethylamino)ethyl...
Paper Details
Title
Drug-loaded pH-responsive polymeric micelles: Simulations and experiments of micelle formation, drug loading and drug release
Published Date
Oct 1, 2017
Volume
158
Pages
709 - 716
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