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Time related effects of non-steroidal anti-inflammatory drugs on Achilles tendinopathy in a murine model:

Published on Jun 1, 2017in Foot & Ankle Orthopaedics
路 DOI :10.1177/2473011417S000002
Adam Bitterman2
Estimated H-index: 2
,
Shuguang Gao2
Estimated H-index: 2
+ 6 AuthorsAnna Plaas41
Estimated H-index: 41
Abstract
Category:Basic Sciences/BiologicsIntroduction/Purpose:Tendinopathy has been identified to result from work and sports-related activities, in many patients. Common treatment for such degenerative tendon pathology includes non-steroidal anti-inflammatory drugs (NSAIDs). Although they provide pain relief, their mechanistic effects, on modulating inflammation associated with tendinopathy is poorly understood. Recent reports suggest impaired functional healing of rat rotator cuff tear repairs when treated in the early postoperative period with ibuprofen, while delayed treatment did not affect healing. We have now identified, using a murine model, a cascade of genes associated with innate inflammation, which influence premature fibrotic scarring without repair. The objective of this study was to evaluate the effects of orally administered ibuprofen on inflammation and wound-healing responses after initiation and during progression of Achilles tendinopathy in a murine model.Methods:All animal experimentation was...
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#1Katie J. Sikes (UIC: University of Illinois at Chicago)H-Index: 2
#2Jun Li (Rush University Medical Center)H-Index: 18
Last. Vincent M. Wang (UIC: University of Illinois at Chicago)H-Index: 26
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ABSTRACTPurpose/Aim of the study: Healthy tendons are maintained in homeostasis through controlled usage of glucose for energy and redox equilibrium. Tendon cell stress imposed by overuse injury or...
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