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Anna Plaas
Rush University
128Publications
41H-index
5,595Citations
Publications 125
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#1Mary Clare McCorry (Cornell University)H-Index: 4
#2Jongkil Kim (Cornell University)H-Index: 1
Last.Lawrence J. Bonassar (Cornell University)H-Index: 58
view all 6 authors...
Abstract Fibrillar collagens are highly prevalent in the extracellular matrix of all connective tissues and therefore commonly used as a biomaterial in tissue engineering applications. In the native environment, collagen fibers are arranged in a complex hierarchical structure that is often difficult to recreate in a tissue engineered construct. Small leucine rich proteoglycans as well as hyaluronan binding proteoglycans, aggrecan and versican, have been implicated in regulating fiber formation. ...
1 CitationsSource
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#1Katie J. SikesH-Index: 2
#2Kristen RennerH-Index: 2
Last.Vincent M. WangH-Index: 26
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2 CitationsSource
#1Katie J. Sikes (UIC: University of Illinois at Chicago)H-Index: 2
#2Jun Li (Rush University Medical Center)H-Index: 18
Last.Vincent M. Wang (UIC: University of Illinois at Chicago)H-Index: 26
view all 7 authors...
ABSTRACTPurpose/Aim of the study: Healthy tendons are maintained in homeostasis through controlled usage of glucose for energy and redox equilibrium. Tendon cell stress imposed by overuse injury or...
2 CitationsSource
Articular cartilage lines the load-bearing surfaces of long bones and undergoes compositional and structural degeneration during osteoarthritis progression. Contrast enhanced microcomputed tomography (μCT) is being applied to a variety of preclinical models, including the mouse, to map structural and compositional properties in 3-D. The thinness (˜30-50 μm) and high cellularity of mouse articular cartilage presents a significant imaging challenge. Our group previously showed that mouse articular...
7 CitationsSource
#1Deva D. ChanH-Index: 12
#2Jun LiH-Index: 18
Last.Anna PlaasH-Index: 41
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Pirfenidone is an anti-inflammatory and anti-fibrotic drug that has shown efficacy in lung and kidney fibrosis. Because inflammation and fibrosis have been linked to the progression of osteoarthritis, we investigated the effects of oral Pirfenidone in a mouse model of cartilage injury, which results in chronic inflammation and joint-wide fibrosis in mice that lack hyaluronan synthase 1 (Has1−/−) in comparison to wild-type. Femoral cartilage was surgically injured in wild-type and Has1−/− mice, a...
2 CitationsSource
#1Adam BittermanH-Index: 2
#2Shuguang GaoH-Index: 2
Last.Anna PlaasH-Index: 41
view all 9 authors...
Category:Basic Sciences/BiologicsIntroduction/Purpose:Tendinopathy has been identified to result from work and sports-related activities, in many patients. Common treatment for such degenerative tendon pathology includes non-steroidal anti-inflammatory drugs (NSAIDs). Although they provide pain relief, their mechanistic effects, on modulating inflammation associated with tendinopathy is poorly understood. Recent reports suggest impaired functional healing of rat rotator cuff tear repairs when tr...
1 CitationsSource
#1Katie J. Trella (UIC: University of Illinois at Chicago)H-Index: 3
#2Jun Li (Rush University Medical Center)H-Index: 18
Last.Robert W. Wysocki (Rush University Medical Center)H-Index: 28
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We have used a murine Achilles tendinopathy model to investigate whether tissue changes (such as collagen disorganization, chondroid metaplasia, and loss of tensile properties) which are broadly characteristic of human tendinopathies, are accompanied by changes in the expression of chromatin-modifying enzymes and the methylation status of promoter regions of tendon cell DNA. Tendinopathy was induced by two intra-tendinous TGF-β1 injections followed by cage activity or treadmill running for up to...
7 CitationsSource
#1Markus A. Wimmer (Rush University)H-Index: 44
#2R.L. Trevino (Rush University)
Last.Anna Plaas (Rush University)H-Index: 41
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