RAG2 involves the Igκ locus demethylation during B cell development
Abstract
The genes encoding the immunoglobulin κ light chain are assembled during B cell development by V(D)J recombination. For efficient rearrangement, the Igκ locus must undergo a series of epigenetic changes. One such epigenetic mark is DNA methylation. The mechanism that the Igκ locus is selectively demethylated at the pre-B cell stage has not previously been characterized. Here, we employed bisulfite DNA-modification assays to analyze the...
Paper Details
Title
RAG2 involves the Igκ locus demethylation during B cell development
Published Date
Aug 1, 2017
Journal
Volume
88
Pages
125 - 134
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