Early versus Delayed Cord-Clamping in Term-Infants Born at Khon Kaen Regional Hospital

Sitthipong Thawinkarn1
Estimated H-index: 1
,
Ussanee Swadpanich1
Estimated H-index: 1
+ 1 AuthorsWoranart Chandrakachorn1
Estimated H-index: 1
Abstract
Objectives To compare the hematological status of early versus delayed cord clamping on hematocrit, hemoglobin and possible adverse outcomes at 48 hours after birth. Study design A randomized, controlled trial. Setting Department of Obstetrics and Gynecology, Khon Kaen Regional Hospital. Material and methods 94 singleton term pregnancies were eligible for inclusion and randomly assigned to a group for either early cord clamping (ECC at the first 10 sec) or delayed cord clamping (DCC at 120 sec) after vaginal delivery. Infants’ hematological status (hematocrit, hemoglobin and total serum bilirubin) and clinicals were evaluated 48 hours after birth. Results All 94 infants were enrolled into the study, 47 were randomized to receive ECC and 47 DCC. At baseline the groups had similar maternal demographic characteristics. At 48 hrs after delivery, the mean infant hematocrit was statistically significant higher in DCC group (56.2 and 49.6 percent, respectively). The proportion of anemic infants was statistically significant higher in the ECC (15.9 %) vs. the DCC (2.2 %) group. No statistically significant differences were found in the proportion of polycythemic infants, hyperbilirubinemia and the use of phototherapy between groups. Conclusion DCC 2 minutes after vaginal delivery improved infant hematocrit and hemoglobin within a physiologic range and this intervention is simple, safe and should be implemented in a strategy to prevent early neonatal anemia.
  • References (23)
  • Citations (3)
References23
Published on Feb 1, 2002in Indian Pediatrics 1.15
Rajesh Gupta2
Estimated H-index: 2
,
Siddharth Ramji10
Estimated H-index: 10
Objective: To study the effects of cord clamping on fron stores of infants born to anemic mothers at 3 months of age. Design: Randomized controlled trial. Setting: Teaching hospital. Methods: Infants born to mothers with hemoglobin (Hb) <100 g/L were randomized at delivery to either immediate cord clamping (early group) or cord clamping delayed till descent of placenta into vagina (delayed group). The outcome measures were infant's hemoglobin and serum ferritin 3 months after delivery. Results: ...
96 Citations
Published on Feb 1, 1997in Indian Pediatrics 1.15
Geethanath Rm1
Estimated H-index: 1
,
Ramji S1
Estimated H-index: 1
+ 1 AuthorsRao Yn1
Estimated H-index: 1
Objective: To determine the effect of timing of cord clamping on iron stores of term infants at 3 months of age. Design: Prospective randomized clinical trial. Setting: Tertiary hospital. Subjects: 107 term neonates born to mothers with uncomplicated pregnancies and with hemoglobin more than 10 g/dl. Methods: The 107 infants were randomized to either early (n=48) or late (n=59) clamping groups at the time of delivery. Outcome measures evaluated were serum ferritin and hemoglobin in the infant at...
56 Citations
Published on Jan 1, 1945
Richard E. Behrman24
Estimated H-index: 24
,
Robert M. Kliegman1
Estimated H-index: 1
,
Hal B. Jenson1
Estimated H-index: 1
Nelson. Textbook of Pediatrics. 15th Ed. Edited by Waldo E Nelson (senior editor) and Richard E Behrman, Robert M Kliegman, and Ann M Marvin (editors). (Pp 2200; £70 hardback.) W B Saunders, 1996. ISBN 0-7216-5578-5 . Hardly anyone encounters a new edition of ‘Nelson’ with an innocent mind: it has simply been the standard paediatric text for the English speaking world for too long. True, ‘Forfar and Arneil’ is a UK production with many virtues, but it hasn’t been around for so long, it costs mor...
4,873 Citations
Published on Oct 1, 2004in Tropical Doctor 0.56
M. O. Emhamed1
Estimated H-index: 1
(Liverpool School of Tropical Medicine),
Rheenen van P4
Estimated H-index: 4
,
Bernard Brabin44
Estimated H-index: 44
(Liverpool School of Tropical Medicine)
This study was conducted to evaluate the haematological effects of the timing of umbilical cord clamping in term infants 24 h after birth in Libya. Mother-infant pairs were randomly assigned to early cord clamping (within 10s after delivery) or delayed clamping (after the cord stopped pulsating). Maternal haematological status was assessed on admission in the delivery room. Infant haematological status was evaluated in cord blood and 24 h after birth. Bilirubin concentration was assessed at 24 h...
57 Citations Source Cite
Published on Sep 1, 1995in The Journal of Pediatrics 3.67
Alfredo Pisacane11
Estimated H-index: 11
,
Basilio De Vizia8
Estimated H-index: 8
+ 4 AuthorsArturo Giustardi1
Estimated H-index: 1
Abstract Iron status of 30 infants who had been breast fed until their first birthday and who had never received cow milk, medicinal iron, or iron-enriched formula and cereals was investigated; 30% were anemic at 12 months of age. The duration of exclusive breast-feeding was significantly longer among nonanemic infants (6.5 vs 5.5 months). None of the infants who were exclusively breast fed for 7 months or more and 43% of those who were breast fed for a shorter time were anemic. Infants who were...
69 Citations Source Cite
Published on Jul 1, 1993in American Journal of Obstetrics and Gynecology 5.73
Mathias Nelle27
Estimated H-index: 27
,
Eugen P Zilow11
Estimated H-index: 11
+ 2 AuthorsOtwin Linderkamp35
Estimated H-index: 35
Objective: This study was done to compare postnatal alterations in blood viscosity, hematocrit value, plasma viscosity, red blood cell aggregation, and red blood cell deformability in term neonates undergoing both early umbilical cord clamping and delivery according to the Leboyer method. Study Design: The umbilical cords of 15 healthy, term infants were clamped within 10 seconds of birth (early cord clamping), and 15 infants delivered according to the Leboyer method were placed on the mother's ...
51 Citations Source Cite
Published on Jan 20, 1996in BMJ 23.56
Alfredo Pisacane11
Estimated H-index: 11
Iron deficiency anaemia in childhood is common even in socially advantaged populations. Low birth weight, early consumption of cows' milk, fast growth rate, and poor dietary iron intake are considered the main risk factors.1 Iron enriched infant formula and cereals have been shown to be effective preventive measures.2 3 In developing countries, where iron deficiency anaemia is common and iron enriched formula and cereals are often not available, preventing iron deficiency is not easy: infants wh...
52 Citations Source Cite
Published on Jul 14, 2010in Acta Paediatrica 2.58
Kim F. Michaelsen74
Estimated H-index: 74
,
N Milman Thanh1
Estimated H-index: 1
(University of Copenhagen),
Gösta Samuelson26
Estimated H-index: 26
In a cohort of term infants (n = 91), followed from birth to 12 months, iron intake was examined by 24-h food records, and iron status by blood samples (haemoglobin (Hb), mean corpuscular volume (MCV), serum values for iron, ferritin and transferrin, and erythrocyte protoporphyrin) at 2, 6 and 9 months. At 9 months of age, 5% had anaemia (Hb < 105 g/l), but none had developed iron deficiency according to strict definitions used in this study (serum ferritin < 13 μg/l and transferrin saturation <...
115 Citations Source Cite
Published on Sep 1, 2006in Obstetrical & Gynecological Survey 2.01
José M. Ceriani Cernadas1
Estimated H-index: 1
,
Guillermo Carroli42
Estimated H-index: 42
+ 6 AuthorsJaime Lardizabal2
Estimated H-index: 2
In present-day Western practice, the umbilical cord is clamped within 10 to 15 seconds after birth, but this has not proved to be better than waiting 1 to 3 minutes. Some studies show that delayed cord clamping prevents iron deficiency anemia in the first year of life, presumably because approximately 80 mL of blood is "transfused" within a minute after birth and 100 mL after 3 minutes. Other studies, however, suggest that delay in clamping the cord may increase the risk of polycythemia, respira...
124 Citations Source Cite
Published on Oct 1, 1992in Acta Paediatrica 2.58
Otwin Linderkamp35
Estimated H-index: 35
(Heidelberg University),
Mathias Nelle27
Estimated H-index: 27
(Heidelberg University)
+ 1 AuthorsEugen P Zilow11
Estimated H-index: 11
(Heidelberg University)
This study was done to compare postnatal alterations in blood viscosity (capillary viscometer) and its determinants: hematocrit, plasma viscosity (capillary viscometer), red cell aggregation (Myrenne aggregometer) and red cell deformability (rheoscope) in the first five days of postnatal life in full-term neonates with early (< 10 s) and late (3 min) cord-clamping. The fetal blood volume of the placenta (“residual placental blood volume”) decreased from 52±8 ml/kg of neonatal body weight after e...
86 Citations Source Cite
  • References (23)
  • Citations (3)
Cited By3
Objective : To compare the hematological status between early and delayed cord clamping and determine adverse outcomes 48 hours after birth Study design : A randomized controlled trial Setting : Department of Obstetrics and Gynecology, Damnoen Saduak Hospital between July 25, 2012 and December 15, 2012 Material and method : 148 singletons uncomplicated term pregnancies were selected according to inclusion criteria of this study. They were randomized to either early (at fist 10 seconds) or delaye...
Objective : To compare fetal hematocrit in different timing of delayed cord clamping and fetomaternal outcome at 48 hours after vaginal births Materials and Methods : 200 term and preterm vaginal births were recruited by inclusion criteria and randomized to 1 and 2 minutes delayed cord clamping followed vaginal births. Fetal hematocrit, hemoglobin, microbilirubin were collected at 48 hours after birth. Primary outcome was the difference in fetal hematocrit among groups. Secondary outcomes were a...
Published on Dec 1, 2017in Lipids in Health and Disease 2.66
Asmaa N. Moustafa1
Estimated H-index: 1
(Minia University),
Mahmoud H. Ibrahim1
Estimated H-index: 1
(Minia University)
+ 3 AuthorsHend M. Moness (Minia University)
Background Although delayed cord clamping (DCC) is a recent WHO recommendation, early cord clamping (ECC) is still a routine practice in many countries. Limited researches studied the effect of delayed cord clamping on oxidative stress in term neonates; In this study we aim to assess the influence of cord clamping either early or late on oxidative stress in term neonates and to evaluate the association of oxidative stress and cord blood lipids.
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