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Early versus Delayed Cord-Clamping in Term-Infants Born at Khon Kaen Regional Hospital

Sitthipong Thawinkarn1
Estimated H-index: 1
,
Ussanee Swadpanich1
Estimated H-index: 1
+ 1 AuthorsWoranart Chandrakachorn1
Estimated H-index: 1
Abstract
Objectives To compare the hematological status of early versus delayed cord clamping on hematocrit, hemoglobin and possible adverse outcomes at 48 hours after birth. Study design A randomized, controlled trial. Setting Department of Obstetrics and Gynecology, Khon Kaen Regional Hospital. Material and methods 94 singleton term pregnancies were eligible for inclusion and randomly assigned to a group for either early cord clamping (ECC at the first 10 sec) or delayed cord clamping (DCC at 120 sec) after vaginal delivery. Infants’ hematological status (hematocrit, hemoglobin and total serum bilirubin) and clinicals were evaluated 48 hours after birth. Results All 94 infants were enrolled into the study, 47 were randomized to receive ECC and 47 DCC. At baseline the groups had similar maternal demographic characteristics. At 48 hrs after delivery, the mean infant hematocrit was statistically significant higher in DCC group (56.2 and 49.6 percent, respectively). The proportion of anemic infants was statistically significant higher in the ECC (15.9 %) vs. the DCC (2.2 %) group. No statistically significant differences were found in the proportion of polycythemic infants, hyperbilirubinemia and the use of phototherapy between groups. Conclusion DCC 2 minutes after vaginal delivery improved infant hematocrit and hemoglobin within a physiologic range and this intervention is simple, safe and should be implemented in a strategy to prevent early neonatal anemia.
  • References (23)
  • Citations (3)
References23
Newest
Published on Jul 14, 2010in Acta Paediatrica 2.27
Kim F. Michaelsen74
Estimated H-index: 74
,
N Milman Thanh1
Estimated H-index: 1
(UCPH: University of Copenhagen),
Gösta Samuelson29
Estimated H-index: 29
In a cohort of term infants (n = 91), followed from birth to 12 months, iron intake was examined by 24-h food records, and iron status by blood samples (haemoglobin (Hb), mean corpuscular volume (MCV), serum values for iron, ferritin and transferrin, and erythrocyte protoporphyrin) at 2, 6 and 9 months. At 9 months of age, 5% had anaemia (Hb < 105 g/l), but none had developed iron deficiency according to strict definitions used in this study (serum ferritin < 13 μg/l and transferrin saturation <...
117 Citations Source Cite
Published on Jul 8, 2009in Cochrane Database of Systematic Reviews 7.75
Walter Prendiville24
Estimated H-index: 24
,
Diana Elbourne1
Estimated H-index: 1
(University of Liverpool),
Susan McDonald16
Estimated H-index: 16
(Mercy Hospital for Women)
Background Expectant management of the third stage of labour involves allowing the placenta to deliver spontaneously or aiding by gravity or nipple stimulation. Active management involves administration of a prophylactic oxytocic before delivery of the placenta, and usually early cord clamping and cutting, and controlled cord traction of the umbilical cord. Objectives The objective of this review was to assess the effects of active versus expectant management on blood loss, post partum haemorrha...
298 Citations Source Cite
Published on Mar 27, 2007in Tropical Medicine & International Health 2.42
Patrick F. van Rheenen15
Estimated H-index: 15
,
Lette de Moor1
Estimated H-index: 1
(UvA: University of Amsterdam)
+ 2 AuthorsBernard Brabin46
Estimated H-index: 46
(LSTM: Liverpool School of Tropical Medicine)
Objectives This study was carried out to assess whether delaying umbilical cord clamping is effective in improving the haematological status of term infants living in a malaria-endemic area, and whether this is associated with complications in infants and mothers. Metyhods We randomly assigned women delivering term babies in Mpongwe Mission Hospital, Zambia, to delayed cord clamping (DCC, n = 46) or immediate cord clamping (controls, n = 45) and followed their infants on a bi-monthly basis until...
58 Citations Source Cite
Published on Mar 21, 2007in JAMA 51.27
Eileen K. Hutton27
Estimated H-index: 27
(McMaster University),
Eman S. Hassan1
Estimated H-index: 1
ContextWith few exceptions, the umbilical cord of every newborn is clamped and cut at birth, yet the optimal timing for this intervention remains controversial.ObjectiveTo compare the potential benefits and harms of late vs early cord clamping in term infants.Data SourcesSearch of 6 electronic databases (on November 15, 2006, starting from the beginning of each): the Cochrane Pregnancy and Childbirth Group trials register, the Cochrane Neonatal Group trials register, the Cochrane library, MEDLIN...
266 Citations Source Cite
Published on Sep 1, 2006in Obstetrical & Gynecological Survey 2.11
José M. Ceriani Cernadas1
Estimated H-index: 1
,
Guillermo Carroli41
Estimated H-index: 41
+ 6 AuthorsJaime Lardizabal2
Estimated H-index: 2
In present-day Western practice, the umbilical cord is clamped within 10 to 15 seconds after birth, but this has not proved to be better than waiting 1 to 3 minutes. Some studies show that delayed cord clamping prevents iron deficiency anemia in the first year of life, presumably because approximately 80 mL of blood is "transfused" within a minute after birth and 100 mL after 3 minutes. Other studies, however, suggest that delay in clamping the cord may increase the risk of polycythemia, respira...
125 Citations Source Cite
Published on Jun 1, 2006in The Lancet 59.10
Camila M Chaparro7
Estimated H-index: 7
(UC Davis: University of California, Davis),
Lynnette M. Neufeld23
Estimated H-index: 23
+ 2 AuthorsKathryn G. Dewey69
Estimated H-index: 69
(UC Davis: University of California, Davis)
Methods 476 mother-infant pairs were recruited at a large obstetrics hospital in Mexico City, Mexico, randomly assigned to delayed clamping (2 min after delivery of the infant's shoulders) or early clamping (around 10 s after delivery), and followed up until 6 months postpartum. Primary outcomes were infant haematological status and iron status at 6 months of age, and analysis was by intention-to-treat. This study is registered with ClinicalTrials.gov, number NCT00298051. Findings 358 (75%) moth...
182 Citations Source Cite
Published on Oct 1, 2004in Tropical Doctor 0.59
M. O. Emhamed1
Estimated H-index: 1
(LSTM: Liverpool School of Tropical Medicine),
Rheenen van P4
Estimated H-index: 4
,
Bernard Brabin46
Estimated H-index: 46
(LSTM: Liverpool School of Tropical Medicine)
This study was conducted to evaluate the haematological effects of the timing of umbilical cord clamping in term infants 24 h after birth in Libya. Mother-infant pairs were randomly assigned to early cord clamping (within 10s after delivery) or delayed clamping (after the cord stopped pulsating). Maternal haematological status was assessed on admission in the delivery room. Infant haematological status was evaluated in cord blood and 24 h after birth. Bilirubin concentration was assessed at 24 h...
57 Citations Source Cite
Published on Jul 1, 2004in Pediatrics 5.40
Subcommittee on Hyperbilirubinemia2
Estimated H-index: 2
Jaundice occurs in most newborn infants. Most jaundice is benign, but because of the potential toxicity of bilirubin, newborn infants must be monitored to identify those who might develop severe hyperbilirubinemia and, in rare cases, acute bilirubin encephalopathy or kernicterus. The focus of this guideline is to reduce the incidence of severe hyperbilirubinemia and bilirubin encephalopathy while minimizing the risks of unintended harm such as maternal anxiety, decreased breastfeeding, and unnec...
1,220 Citations Source Cite
Published on Apr 1, 2002in Journal of Nutrition 4.42
Pattanee Winichagoon22
Estimated H-index: 22
(MU: Mahidol University)
Thailand has addressed nutrition in national development policy since the mid-1970s including efforts to reduce iron deficiency anemia. Nutritional improvement has been implemented as an integral part of primary health care and community development extending beyond government services to include community participation. Utilization of village health volunteers has been a crucial feature of the program. Available data indicate that anemia rates have declined among pregnant women and preschool ch...
46 Citations Source Cite
Cited By3
Newest
Published on Dec 1, 2017in Lipids in Health and Disease 2.65
Asmaa N. Moustafa1
Estimated H-index: 1
(Minia University),
Mahmoud H. Ibrahim1
Estimated H-index: 1
(Minia University)
+ 3 AuthorsHend M. Moness (Minia University)
Background Although delayed cord clamping (DCC) is a recent WHO recommendation, early cord clamping (ECC) is still a routine practice in many countries. Limited researches studied the effect of delayed cord clamping on oxidative stress in term neonates; In this study we aim to assess the influence of cord clamping either early or late on oxidative stress in term neonates and to evaluate the association of oxidative stress and cord blood lipids.
Source Cite
Objective : To compare fetal hematocrit in different timing of delayed cord clamping and fetomaternal outcome at 48 hours after vaginal births Materials and Methods : 200 term and preterm vaginal births were recruited by inclusion criteria and randomized to 1 and 2 minutes delayed cord clamping followed vaginal births. Fetal hematocrit, hemoglobin, microbilirubin were collected at 48 hours after birth. Primary outcome was the difference in fetal hematocrit among groups. Secondary outcomes were a...
Nuanpun Tanmoun1
Estimated H-index: 1
Objective : To compare the hematological status between early and delayed cord clamping and determine adverse outcomes 48 hours after birth Study design : A randomized controlled trial Setting : Department of Obstetrics and Gynecology, Damnoen Saduak Hospital between July 25, 2012 and December 15, 2012 Material and method : 148 singletons uncomplicated term pregnancies were selected according to inclusion criteria of this study. They were randomized to either early (at fist 10 seconds) or delaye...