Review paper
Microglial Activation in the Pathogenesis of Huntington’s Disease
Abstract
Huntington’s disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by expanded CAG trinucleotide repeats (> 36) in exon 1 of HTT gene that encodes huntingtin protein. Although HD is characterized by a predominant loss of neurons in the striatum and cortex, previous studies point to a critical role of aberrant accumulation of mutant huntingtin in microglia that contributes to the progressive neurodegeneration in HD,...
Paper Details
Title
Microglial Activation in the Pathogenesis of Huntington’s Disease
Published Date
Jun 19, 2017
Volume
9
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