Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes

Summary Altered metabolism is a hallmark of cancers, including shifting oxidative phosphorylation to glycolysis and up‐regulating glutaminolysis to divert carbon sources into biosynthetic pathways that promote proliferation and survival. Therefore, metabolic inhibitors represent promising anti‐cancer drugs. However, T cells must rapidly divide and survive in harsh microenvironments to mediate anti‐cancer effects. Metabolic profiles of cancer...