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Byram W. Bridle
University of Guelph
44Publications
16H-index
767Citations
Publications 44
Newest
#1María Carla Rosales Gerpe (U of G: University of Guelph)H-Index: 1
#2Laura P. van Lieshout (U of G: University of Guelph)H-Index: 3
Last.Peter J. Krell (U of G: University of Guelph)H-Index: 32
view all 12 authors...
Lung gene therapy requires efficient transduction of slow-replicating epithelia and stable expression of delivered transgenes in the respiratory tract. Lentiviral vectors (LV) have the ideal coding...
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#1Jonathan PolH-Index: 16
#2Byram W. Bridle (U of G: University of Guelph)H-Index: 16
Last.Brian D. Lichty (McMaster University)H-Index: 37
view all 3 authors...
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#1Cristine J. Reitz (U of G: University of Guelph)H-Index: 7
#2Faisal J. Alibhai (U of G: University of Guelph)H-Index: 9
Last.Tami A. Martino (U of G: University of Guelph)H-Index: 22
view all 7 authors...
Reperfusion of patients after myocardial infarction (heart attack) triggers cardiac inflammation that leads to infarct expansion and heart failure (HF). We previously showed that the circadian mechanism is a critical regulator of reperfusion injury. However, whether pharmacological targeting using circadian medicine limits reperfusion injury and protects against HF is unknown. Here, we show that short-term targeting of the circadian driver REV-ERB with SR9009 benefits long-term cardiac repair po...
1 CitationsSource
#1Jacob P. van Vloten (Ontario Veterinary College)H-Index: 2
#2Elaine M. Klafuric (Ontario Veterinary College)H-Index: 1
Last.Byram W. Bridle (Ontario Veterinary College)H-Index: 16
view all 7 authors...
As the development and clinical application of cancer immunotherapies continue to expand, so does the need for novel methods to dissect their mechanisms of action. Antibodies are important effector molecules in cancer therapies due to their potential to bind directly to surface-expressed antigens and facilitate Fc receptor-mediated uptake of antigens by antigen-presenting cells. Quantifying antibodies that are specific for defined antigens is straightforward. However, we describe herein a precli...
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#1Darrick L. Yu (U of G: University of Guelph)H-Index: 2
#2Ashley A. Stegelmeier (U of G: University of Guelph)H-Index: 1
Last.Sarah K. Wootton (U of G: University of Guelph)H-Index: 14
view all 9 authors...
An integral step in the development of solid tumors is the recruitment of blood vessels to fuel tumor growth. Antiangiogenic therapies can inhibit this process and control solid tumor growth. Thrombospondin-1 is an antiangiogenic protein possessing three type I repeats (3TSR) near the center of the protein and a CD47-binding peptide (CD47) in its C-terminus. Previously, we showed that treatment with recombinant 3TSR induces tumor regression, normalizes tumor vasculature, and improves uptake of c...
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#1Jacob P. van Vloten (Ontario Veterinary College)H-Index: 2
#2Lisa A. Santry (Ontario Veterinary College)H-Index: 4
Last.Byram W. Bridle (Ontario Veterinary College)H-Index: 16
view all 8 authors...
Immunotherapies are at the forefront of the fight against cancers, and researchers continue to develop and test novel immunotherapeutic modalities. Ideal cancer immunotherapies induce a patient’s immune system to kill their own cancer and develop long-lasting immunity. Research has demonstrated a critical requirement for CD8 + and CD4 + T cells in achieving durable responses. In the path to the clinic, researchers require robust tools to effectively evaluate the capacity for immunotherapies to g...
1 CitationsSource
#1Kathy Matuszewska (U of G: University of Guelph)H-Index: 1
#2Lisa A. Santry (U of G: University of Guelph)H-Index: 3
Last.James J. Petrik (U of G: University of Guelph)H-Index: 24
view all 9 authors...
Purpose: Intravenous delivery of oncolytic viruses often leads to tumor vascular shutdown, resulting in decreased tumor perfusion and elevated tumor hypoxia. We hypothesized that using 3TSR to normalize tumor vasculature prior to administration of an oncolytic Newcastle disease virus (NDV) would enhance virus delivery and trafficking of immunologic cell subsets to the tumor core, resulting in systemically enhanced immunotherapy and regression of advanced-stage epithelial ovarian cancer (EOC). Ex...
6 CitationsSource
Last.Khalil KarimiH-Index: 2
view all 8 authors...
Myeloid cells represent a diverse range of innate leukocytes that are crucial for mounting successful immune responses against viruses. These cells are responsible for detecting pathogen-associated molecular patterns, thereby initiating a signaling cascade that results in the production of cytokines such as interferons to mitigate infections. The aim of this review is to outline recent advances in our knowledge of the roles that neutrophils and inflammatory monocytes play in initiating and coord...
2 CitationsSource
#1Jonathan PolH-Index: 16
Last.Brian D. LichtyH-Index: 37
view all 14 authors...
8 CitationsSource
#1María Carla Rosales Gerpe (U of G: University of Guelph)H-Index: 1
#2Jacob P. van Vloten (U of G: University of Guelph)H-Index: 1
Last.Sarah K. Wootton (U of G: University of Guelph)H-Index: 14
view all 9 authors...
Organotypic slice cultures recapitulate many features of an intact organ, including cellular architecture, microenvironment, and polarity, making them an ideal tool for the ex vivo study of viruses and viral vectors. Here, we describe a procedure for generating precision-cut ovine and murine tissue slices from agarose-perfused normal and murine melanoma tumor-bearing lungs. Furthermore, we demonstrate that these precision-cut lung slices can be maintained up to 1 month and can be used for a rang...
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