Lipid/alginate nanoparticle-loaded in situ gelling system tailored for dexamethasone nasal delivery

In this study, we suggest the development of nanoparticle loaded in situ gelling system suitable for corticosteroid nasal delivery. We propose lipid/alginate nanoparticles (size 252.3 ± 2.4 nm, polydispersity index 0.241, zeta-potential −31.7 ± 1.0 mV, dexamethasone (Dex) content 255 ± 7 μg ml−1) dispersed in pectin solution (5 mg ml−1) that undergoes a sol-gel phase transition triggered by Ca2+ present in nasal mucosa. The viscoelasticity of...