Review paper
Senescence in Health and Disease
Abstract
Many cellular stresses activate senescence, a persistent hyporeplicative state characterized in part by expression of the p16INK4a cell-cycle inhibitor. Senescent cell production occurs throughout life and plays beneficial roles in a variety of physiological and pathological processes including embryogenesis, wound healing, host immunity, and tumor suppression. Meanwhile, the steady accumulation of senescent cells with age also has adverse...
Paper Details
Title
Senescence in Health and Disease
Published Date
Jun 1, 2017
Journal
Volume
169
Issue
6
Pages
1000 - 1011
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Notes
History