PAI‐1 gain‐of‐function genotype, factors increasing PAI‐1 levels, and airway obstruction: The GALA II Cohort

Summary Background PAI ‐1 gain‐of‐function variants promote airway fibrosis and are associated with asthma and with worse lung function in subjects with asthma. Objective We sought to determine whether the association of a gain‐of‐function polymorphism in plasminogen activator inhibitor‐1 ( PAI ‐1) with airway obstruction is modified by asthma status, and whether any genotype effect persists after accounting for common exposures that increase...