Original paper
TCR Signaling and CD28/CTLA-4 Signaling Cooperatively Modulate T Regulatory Cell Homeostasis
Abstract
Foxp3+ T regulatory cells (Tregs), conventional CD4+Foxp3− T cells, and CD8+ T cells represent heterogeneous populations composed of naive phenotype (NP, CD44low) and memory phenotype (MP, CD44high) subpopulations. NP and MP subsets differ in their activation state, contribution to immune function, and capacity to proliferate in vivo. To further understand the factors that contribute to the differential homeostasis of NP/MP subsets, we examined...
Paper Details
Title
TCR Signaling and CD28/CTLA-4 Signaling Cooperatively Modulate T Regulatory Cell Homeostasis
Published Date
Feb 15, 2017
Journal
Volume
198
Issue
4
Pages
1503 - 1511
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Notes
History