Early skin denervation in hereditary and iatrogenic transthyretin amyloid neuropathy

To elucidate early skin denervation in hereditary transthyretin (TTR) amyloidosis and iatrogenic TTR amyloidosis.We investigated intraepidermal nerve fiber density (IENFD) and clinical findings in 32 patients with hereditary TTR amyloidosis, 11 asymptomatic mutation carriers, 6 patients with iatrogenic TTR amyloidosis, and 23 healthy volunteers.IENFD values were reduced in patients with the V30M mutation (1.9 ± 2.1 per 1 mm), patients with...