Gas6 Promotes Inflammatory (CCR2^hiCX3CR1^lo) Monocyte Recruitment in Venous Thrombosis

Coagulation and inflammation are inter-related. Gas6 (growth arrest-specific 6) promotes venous thrombosis and participates to inflammation through endothelial-innate immune cell interactions. Innate immune cells can provide the initiating stimulus for venous thrombus development. We hypothesize that Gas6 promotes monocyte recruitment during venous thrombosis.Deep venous thrombosis was induced in wild-type and Gas6-deficient (-/-) mice using 5%...