Review paper
Overcoming aromatase inhibitor resistance in breast cancer: possible mechanisms and clinical applications
Abstract
Estrogen plays crucial roles in the progression of hormone-dependent breast cancers through activation of nuclear estrogen receptor α (ER). Estrogen is produced locally from circulating inactive steroids and adrenal androgens in postmenopausal women. However, conversion by aromatase is a rate-limiting step in intratumoral estrogen production in breast cancer. Aromatase inhibitors (AIs) inhibit the growth of hormone-dependent breast cancers by...
Paper Details
Title
Overcoming aromatase inhibitor resistance in breast cancer: possible mechanisms and clinical applications
Published Date
Apr 7, 2017
Journal
Volume
25
Issue
4
Pages
379 - 391
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