Plasminogen activator inhibitor‐1 is associated with leukocyte telomere length in American Indians: findings from the Strong Heart Family Study

Essentials•Plasminogen activator inhibitor‐1 (PAI‐1) advanced cellular senescence in experiment studies.•No population study exists on the association between PAI‐1 and biological aging in American Indians.•We found cross‐sectional and longitudinal associations between higher PAI‐1 and shorter telomere length.•Our findings suggest a pathway linking PAI‐1 with biological aging beyond metabolic factors.Summary: BackgroundPlasminogen activator...