Original paper
Development of Damaged Nucleoside Mimics for Inhibition of Their Repair Enzymes
Abstract
8-Oxo-2'-deoxyguanosine (8-oxo-dG) is a representative of nucleoside damage, which is generated by the reaction of the 8 position of dG with reactive oxygen species. Abundant 8-oxo-dG in DNA exhibits genotoxicity and has been linked to aging and disease, such as cancer. As the metabolism of cancer cells is much faster than that of normal cells, the oxidized product of the oligonucleotides and the nucleotide pool produces 8-oxo-dG and...
Paper Details
Title
Development of Damaged Nucleoside Mimics for Inhibition of Their Repair Enzymes
Published Date
Mar 1, 2017
Journal
Volume
137
Issue
3
Pages
293 - 300
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Notes
History