Redox Control of Protein Kinase G Iα Fine-Tunes the Frank-Starling Law of the Heart in Vivo by Regulating Diastolic Relaxation

The Frank-Starling law describes a regulatory mechanism that allows the amount of blood that enters the heart to be precisely matched with the amount that is pumped out to the arterial circulation, independently of external regulation. Mechanisms that contribute to the Frank-Starling response include stretch-induced increases in myofilament overlap, myofilament Ca2+ sensitivity and actin-myosin cross-bridge formation. Recently, it was reported...