Match!

Cortisol levels in fingernails, neurocognitive performance and clinical variables in euthymic bipolar I disorder

Published on Nov 17, 2018in World Journal of Biological Psychiatry4.04
· DOI :10.1080/15622975.2017.1298838
Andres Herane-Vives4
Estimated H-index: 4
('KCL': King's College London),
Anthony J. Cleare50
Estimated H-index: 50
('KCL': King's College London)
+ 6 AuthorsAllan H. Young75
Estimated H-index: 75
('KCL': King's College London)
Abstract
OBJECTIVES: Neurocognitive impairment has been found in bipolar patients. Hypercortisolemia is one possible cause but there has been no agreement on this. Previous sampling methods assessed only acute cortisol levels, whereas the association between cortisol and psychopathology might be better understood by investigating chronic levels. Fingernails are a novel method for measuring chronic cortisol concentration (CCC). Here, we measured CCC in euthymic bipolar disorder I (BD-I) patients and healthy controls using fingernails to investigate whether differences in CCC influenced neurocognitive performance. We also investigated whether differences in clinical illness variables influenced CCC in euthymic BD-I patients. METHODS: A previous study demonstrated neurocognitive impairment in euthymic BD-I patients. The current study included a portion of this sample: 40 BD-I versus 42 matched controls who provided fingernail samples. RESULTS: There was no statistically significant difference in CCC between controls and BD-I (P = .09). Logistic regression analyses revealed that euthymic bipolar I subjects with more than five years of current euthymia had decreased odds of having higher fingernail cortisol concentration (>71.2 pg/mg) compared to those with less than 1.5 years (P = .04). There was no association between CCC and cognitive impairment in all domains before and after adjustment for age and sex. CONCLUSIONS: The current evidence suggests CCC is not a trait biomarker in euthymic BD-I (BD-I). Longer periods of stability in affective disorders are associated with lower CCC. Fingernail cortisol does not seem to be implicated in neurocognitive impairment and BD-I. Future studies may investigate CCC in different illness phases of BD-I.
  • References (63)
  • Citations (1)
📖 Papers frequently viewed together
61 Citations
2009
1 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References63
Newest
#1Shuhei Izawa (NIOSH: National Institute for Occupational Safety and Health)H-Index: 11
#2Keiichi Miki (NIOSH: National Institute for Occupational Safety and Health)H-Index: 3
Last. Fumiharu Togo (UTokyo: University of Tokyo)H-Index: 22
view all 8 authors...
Summary The cortisol level in fingernails may reflect the hormone's cumulative production over a long period, but the notions have not been fully established. In this study, we investigated the association of cortisol in fingernails with cortisol accumulation over a long period (hair cortisol) and over a relatively short period (salivary cortisol). In study 1, hair and fingernail samples were collected from 58 middle-aged and elderly men. The cortisol level in hair samples was moderately associa...
22 CitationsSource
#1Christian Otte (Charité)H-Index: 41
#2Katja Wingenfeld (Charité)H-Index: 32
Last. Kim Hinkelmann (Charité)H-Index: 16
view all 11 authors...
Memory and executive function are often impaired in patients with major depression, while cortisol secretion is increased. Mineralocorticoid receptors (MR) are abundantly expressed in the hippocampus and in the prefrontal cortex, brain areas critical for memory, executive function, and cortisol inhibition. Here, we investigated whether MR stimulation with fludrocortisone (1) improves memory and executive function and (2) decreases cortisol secretion in depressed patients and healthy individuals....
44 CitationsSource
#1Tobias Stalder (TUD: Dresden University of Technology)H-Index: 35
#2A. Tietze (TUD: Dresden University of Technology)H-Index: 5
Last. Clemens Kirschbaum (TUD: Dresden University of Technology)H-Index: 105
view all 6 authors...
Summary Hair cortisol concentrations (HCC) are assumed to reflect integrated long-term cortisol levels and have been proposed as a promising endocrine marker of chronic psychological stress. The current study examined HCC in relation to caregiving burden, a well-established naturalistic model of chronic stress in humans. HCC and relevant psychosocial data were examined in 20 caregivers of relatives with dementia and 20 non-caregiver controls matched for age and sex. Results revealed elevated HCC...
54 CitationsSource
#1Y W Cheung Eric (Castle Peak Hospital)H-Index: 1
#2Rozmin Halari (Centre for Mental Health)H-Index: 23
Last. Allan H. Young (Centre for Mental Health)H-Index: 75
view all 5 authors...
Abstract Background Data from euthymic patients with Bipolar Disorder (BD) has shown cognitive impairment and the notion that sufferers of BD achieve full recovery between illness episodes is questionable. These findings have not been replicated in a Chinese population. The present study examined the cognitive profile of euthymic Chinese patients with Bipolar 1 Disorder (BD-1) and matched healthy control participants. Methods Euthymic patients with BD-1 and matched controls ( n =104 in total) co...
16 CitationsSource
#1Ulrike Rimmele (University of Geneva)H-Index: 4
#2Luciana Besedovsky (University of Tübingen)H-Index: 10
Last. Jan Born (University of Tübingen)H-Index: 96
view all 4 authors...
Memory retrieval is impaired at very low as well as very high cortisol levels, but not at intermediate levels. This inverted-U-shaped relationship between cortisol levels and memory retrieval may originate from different roles of the mineralocorticoid (MR) and glucocorticoid receptor (GR) that bind cortisol with distinctly different affinity. Here, we examined the role of MRs and GRs in human memory retrieval using specific receptor antagonists. In two double-blind within-subject, cross-over des...
53 CitationsSource
1 Citations
#1Stuart Watson (Newcastle University)H-Index: 23
#2Peter Gallagher (Newcastle University)H-Index: 33
Last. I. N. Ferrier (Newcastle University)H-Index: 64
view all 8 authors...
Background Deficits in neuropsychological performance are found in patients with bipolar disorder and represent a potential treatment target for novel therapeutic strategies. We have previously demonstrated a beneficial effect on spatial working memory (SWM) of treatment for 1 week with the progesterone and glucocorticoid receptor antagonist mifepristone, evident 2 weeks after the cessation of treatment. Methods We examined the longer-term efficacy of 600 mg/day of mifepristone as an adjunctive ...
72 CitationsSource
#1Laura Manenschijn (EUR: Erasmus University Rotterdam)H-Index: 14
#2A.T. SpijkerH-Index: 10
Last. Elisabeth F.C. van Rossum (EUR: Erasmus University Rotterdam)H-Index: 41
view all 8 authors...
47 CitationsSource
#1Berry J. van Holland (UvA: University of Amsterdam)H-Index: 5
#2Monique H. W. Frings-Dresen (UvA: University of Amsterdam)H-Index: 46
Last. Judith K. Sluiter (UvA: University of Amsterdam)H-Index: 40
view all 3 authors...
Purpose The aims of this study were to investigate (1) the concurrent relationship between short-term and long-term stress reactivity measured by cortisol excretion and (2) the relationship of these physiological stress effects with self-reported stress and need for recovery after work (NFR).
49 CitationsSource
#2Andrea GierensH-Index: 2
Last. Wolff Schlotz (University of Regensburg)H-Index: 36
view all 5 authors...
The impact of stress on health and disease is an important research topic in psychosomatic medicine. Because research on hypothalamic-pituitary-adrenal (HPA) axis regulation under controlled laboratory studies lacks ecological validity, it needs to be complemented by a research program that includes
121 CitationsSource
Cited By1
Newest
#1Andres Herane-Vives ('KCL': King's College London)H-Index: 4
#2V. De Angel ('KCL': King's College London)H-Index: 2
Last. Anthony J. Cleare ('KCL': King's College London)H-Index: 50
view all 10 authors...
4 CitationsSource