Review paper
TET Methylcytosine Oxidases in T Cell and B Cell Development and Function
Abstract
DNA methylation is established by DNA methyltransferases and is a key epigenetic mark. Ten-eleven translocation (TET) proteins are enzymes that oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further oxidization products (oxi-mCs), which indirectly promote DNA demethylation. Here, we provide an overview of the effect of TET proteins and altered DNA modification status in T and B cell development and function. We summarize...
Paper Details
Title
TET Methylcytosine Oxidases in T Cell and B Cell Development and Function
Published Date
Mar 31, 2017
Journal
Volume
8
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