Estrogen receptor α wields treatment-specific enhancers between morphologically similar endometrial tumors

Significance This study shows that the hormonal environment in which a tumor originates may affect a hormone receptor’s enhancer usage. We further show that enhancer function is less tissue specific than previously thought. By implementing ChIP sequencing in a unique patient cohort, we compared estrogen receptor α (ERα) profiles in endometrial tumors that developed in different hormonal environments and integrated these comparisons with...