Original paper
Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells
Abstract
Autologous T cells engineered to express chimeric antigen receptor against the B cell antigen CD19 (CAR19) are achieving marked leukemic remissions in early-phase trials but can be difficult to manufacture, especially in infants or heavily treated patients. We generated universal CAR19 (UCART19) T cells by lentiviral transduction of non-human leukocyte antigen-matched donor cells and simultaneous transcription activator-like effector nuclease...
Paper Details
Title
Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells
Published Date
Jan 25, 2017
Volume
9
Issue
374
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Notes
History