Original paper
SMiLE-seq identifies binding motifs of single and dimeric transcription factors
Abstract
Resolving the DNA-binding specificities of transcription factors (TFs) is of critical value for understanding gene regulation. Here, we present a novel, semiautomated protein-DNA interaction characterization technology, selective microfluidics-based ligand enrichment followed by sequencing (SMiLE-seq). SMiLE-seq is neither limited by DNA bait length nor biased toward strong affinity binders; it probes the DNA-binding properties of TFs over a...
Paper Details
Title
SMiLE-seq identifies binding motifs of single and dimeric transcription factors
Published Date
Jan 16, 2017
Journal
Volume
14
Issue
3
Pages
316 - 322
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Notes
History