Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
Abstract
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD...
Paper Details
Title
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
Published Date
Feb 6, 2017
Journal
Volume
49
Issue
3
Pages
416 - 425
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