Edwin K. Silverman
Brigham and Women's Hospital
Physical therapyCOPDDiseaseMedicineBiology
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Publications 696
#1Alessandro N. Franciosi (RCSI: Royal College of Surgeons in Ireland)H-Index: 3
#2Brian D. Hobbs (Brigham and Women's Hospital)H-Index: 10
Last. Noel G. McElvaney (RCSI: Royal College of Surgeons in Ireland)H-Index: 61
view all 10 authors...
#1Spyridon Fortis (UI: University of Iowa)H-Index: 6
#2Alejandro P. Comellas (UI: University of Iowa)H-Index: 24
Last. Emily S. Wan (Brigham and Women's Hospital)H-Index: 20
view all 8 authors...
One quarter of individuals with Preserved Ratio Impaired Spirometry (PRISm) will develop airflow obstruction, but there are no established methods to identify these individuals. We examined the utility of FVC/TLC in identifying features of obstructive lung disease. The ratio of post-bronchodilator FVC and TLCCT from chest CT (FVC/TLCCT) among current and former smokers with PRISm (FEV1/FVC ≥ 0.7 and FEV1 < 80%) in COPDGene was used to stratify subjects into quartiles: very high, high, low, and v...
#1Dongxue Mao (BCM: Baylor College of Medicine)H-Index: 2
#2Chloe M. Reuter (Stanford University)H-Index: 7
Last. Matthew T. Wheeler (Stanford University)H-Index: 30
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EIF2AK1 and EIF2AK2 encode members of the eukaryotic translation initiation factor 2 alpha kinase (EIF2AK) family that inhibits protein synthesis in response to physiologic stress conditions. EIF2AK2 is also involved in innate immune response and the regulation of signal transduction, apoptosis, cell proliferation, and differentiation. Despite these findings, human disorders associated with deleterious variants in EIF2AK1 and EIF2AK2 have not been reported. Here, we describe the identification o...
#1Georg Hahn (Harvard University)
#2Sharon M. Lutz (Harvard University)H-Index: 20
Last. Christoph Lange (Harvard University)H-Index: 80
view all 8 authors...
locStra is an R-package for the analysis of regional and global population stratification in whole genome sequencing studies, where regional stratification refers to the substructure defined by the loci in the region. Population substructure can be assessed based on the genetic covariance matrix, the genomic relationship matrix, and the unweighted/weighted genetic Jaccard similarity matrix. Using a sliding window approach, the regional similarity matrices are compared to the global ones, based o...
#1Julia Ford (Harvard University)H-Index: 2
#2Xinyi Liu (Brigham and Women's Hospital)H-Index: 2
Last. Jeffrey A. Sparks (Harvard University)H-Index: 16
view all 9 authors...
OBJECTIVES: Inflamed airways are hypothesized to contribute to rheumatoid arthritis (RA) pathogenesis due to RA-related autoantibody production, and smoking is the strongest environmental RA risk factor. However, the role of chronic airway diseases in RA development is unclear. We investigated whether asthma or COPD were associated with RA. METHODS: We performed a prospective cohort study of 205,153 women in the Nurses' Health Study (NHS, 1988-2014) and NHSII (1991-2015). Exposures were self-rep...
#1Julian Hecker (Harvard University)H-Index: 5
#2Ingo Ruczinski (Johns Hopkins University)H-Index: 47
Last. Christoph Lange (Harvard University)H-Index: 80
view all 6 authors...
In the analysis of current life science datasets, we often encounter scenarios in which the application of asymptotic theory to hypothesis testing can be problematic. Besides improved asymptotic results, permutation/simulation-based tests are a general approach to address this issue. However, these randomized tests can impose a massive computational burden, for example, in scenarios in which large numbers of statistical tests are computed, and the specified significance level is very small. Stop...
#1Paola Paci (National Research Council)H-Index: 16
#2Giulia Fiscon (National Research Council)H-Index: 8
Last. Edwin K. Silverman (Brigham and Women's Hospital)H-Index: 94
view all 11 authors...
Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous syndrome. Network-based analysis implemented by SWIM software can be exploited to identify key molecular switches - called “switch genes” - for the disease. Genes contributing to common biological processes or defining given cell types are usually co-regulated and co-expressed, forming expression network modules. Consistently, we found that the COPD correlation network built by SWIM consists of three well-characterized m...
#1Enrico Maiorino (NU: Northeastern University)
#2Seung Han Baek (Brigham and Women's Hospital)
Last. A. Sharma (Brigham and Women's Hospital)H-Index: 53
view all 10 authors...
The molecular and clinical features of a complex disease can be influenced by other diseases affecting the same individual. Understanding disease-disease interactions is therefore crucial for revealing shared molecular mechanisms among diseases and designing effective treatments. Here we introduce Flow Centrality (FC), a network-based approach to identify the genes mediating the interaction between two diseases in a protein-protein interaction network. We focus on asthma and COPD, two chronic re...
#1Esther PompeH-Index: 6
#2Matthew StrandH-Index: 28
Last. Barry J. MakeH-Index: 55
view all 14 authors...
A large proportion of emphysema progression in smokers with and those without airflow limitation was not accounted for by changes in forced expiratory volume in 1 second, suggesting that CT-detecte...
#1David C. LaFon (UAB: University of Alabama at Birmingham)H-Index: 3
#2Surya P. Bhatt (UAB: University of Alabama at Birmingham)H-Index: 24
Last. J. Michael WellsH-Index: 17
view all 18 authors...
Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality worldwide [1]. Pulmonary hypertension (PH) has been associated with reduced survival among individuals with COPD [2] and is an independent risk factor for mortality following acute exacerbations of COPD (AECOPD) [3]. Measurement of the pulmonary artery to aorta (PA:A) ratio by computed tomography (CT) and assessment of PA enlargement (PA:A>1) outperforms echocardiography in identifying PH in severe COPD [4], a...