BCL11B gene heterozygosity causes weight loss accompanied by increased energy consumption, but not defective adipogenesis, in mice

BCL11B is a zinc finger-type transcription factor that regulates the development of the white adipose tissue (WAT), skin, central nervous system, and immune system. BCL11B is required for proper adipocyte differentiation, and BCL11B−/− embryos at E19.5 have very low amounts of the subcutaneous WAT. Here, we demonstrated that BCL11B+/− mice have lower body weight than BCL11B+/+ mice, whereas the expression of adipogenic marker genes in the WAT...