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Jun Inoue
University of Tokyo
42Publications
17H-index
1,008Citations
Publications 42
Newest
#1Masamori Iwase (UTokyo: University of Tokyo)H-Index: 1
#2Kyoko Watanabe (Tokyo University of Agriculture)
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
view all 7 authors...
ABSTRACTSterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate the expression of genes involved in fatty acid and cholesterol biosynthetic pathways. The present...
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#1Takashi Sasaki (UTokyo: University of Tokyo)H-Index: 34
#2Moeko Mita (UTokyo: University of Tokyo)H-Index: 3
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
view all 10 authors...
TGR5, a member of the G protein-coupled receptor (GPCR) family, is activated by bile acids. Because TGR5 promotes energy expenditure and improves glucose homeostasis, it is recognized as a key target in treating metabolic diseases. We previously showed that nomilin, a citrus limonoid, activates TGR5 and confers anti-obesity and anti-hyperglycemic effects in mice. Information on the TGR5–nomilin interaction regarding molecular structure, however, has not been reported. In the present study, we fo...
6 CitationsSource
#1Jun Inoue (UTokyo: University of Tokyo)H-Index: 17
#2Yusuke Ihara (UTokyo: University of Tokyo)H-Index: 1
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
view all 10 authors...
BCL11B is a zinc finger-type transcription factor that regulates the development of the white adipose tissue (WAT), skin, central nervous system, and immune system. BCL11B is required for proper adipocyte differentiation, and BCL11B−/− embryos at E19.5 have very low amounts of the subcutaneous WAT. Here, we demonstrated that BCL11B+/− mice have lower body weight than BCL11B+/+ mice, whereas the expression of adipogenic marker genes in the WAT was comparable between BCL11B+/+ and BCL11B+/− mice. ...
1 CitationsSource
#1Yen-Chou KuanH-Index: 1
#2Tsutomu HashidumeH-Index: 7
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
view all 7 authors...
Abstract Sterol regulatory element-binding proteins (SREBPs) are the key transcription factors that modulate lipid biosynthesis. SREBPs are synthesized as endoplasmic reticulum-bound precursors that require proteolytic activation in the Golgi apparatus. The stability and maturation of precursor SREBPs depend on their binding to SREBP cleavage-activating protein (SCAP), which escorts the SCAP-SREBP complex to the Golgi apparatus. In this study, we identified heat shock protein (HSP) 90 as a novel...
13 CitationsSource
#1Jun InoueH-Index: 17
#2Yusuke IharaH-Index: 1
Last.Ryuichiro SatoH-Index: 37
view all 11 authors...
The differentiation of preadipocytes into adipocytes is controlled by several transcription factors, including peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα), which are known as master regulators of adipogenesis. BCL11B is a zinc finger-type transcription factor that regulates the development of the skin and central nervous and immune systems. Here, we found that BCL11B was expressed in the white adipose tissue (WAT), particularly the subcutane...
7 CitationsSource
#1Ayasa OchiaiH-Index: 2
#2Shingo MiyataH-Index: 17
Last.Ryuichiro SatoH-Index: 37
view all 6 authors...
A high level of plasma low-density lipoprotein (LDL) cholesterol is considered a risk factor for atherosclerosis. Because the hepatic LDL receptor (LDLR) is essential for clearing plasma LDL cholesterol, activation of LDLR is a promising therapeutic target for patients with atherosclerotic disease. Here we demonstrated how the flavonoid kaempferol stimulated the gene expression and activity of LDLR in HepG2 cells. The kaempferol-mediated stimulation of LDLR gene expression was completely inhibit...
7 CitationsSource
#1Ryuto Maruyama (UTokyo: University of Tokyo)H-Index: 4
#2Makoto Shimizu (UTokyo: University of Tokyo)H-Index: 31
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
view all 6 authors...
Activating transcription factor 4 (ATF4) is a transcription factor with an important biological activity. ATF4 is induced by various stresses, such as endoplasmic reticulum stress, through the phosphorylation of eukaryotic translation initiation factor 2α. ATF4 is also involved in lipid metabolism. In the present study, we performed a microarray experiment to identify new ATF4 target genes, particularly those involved in lipid metabolism, and identified C12orf39, CSTA, and CALCB as novel ATF4 ta...
3 CitationsSource
#1Tsutomu Hashidume (UTokyo: University of Tokyo)H-Index: 7
#2Asuka Kato (UTokyo: University of Tokyo)H-Index: 1
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
view all 12 authors...
Soy protein β-conglycinin has serum lipid-lowering and anti-obesity effects. We showed that single ingestion of β-conglycinin after fasting alters gene expression in mouse liver. A sharp increase in fibroblast growth factor 21 (FGF21) gene expression, which is depressed by normal feeding, resulted in increased postprandial circulating FGF21 levels along with a significant decrease in adipose tissue weights. Most increases in gene expressions, including FGF21, were targets for the activating tran...
8 CitationsSource
#1Ryuto Maruyama (UTokyo: University of Tokyo)H-Index: 4
#2Makoto Shimizu (UTokyo: University of Tokyo)H-Index: 31
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
view all 5 authors...
Fibroblast growth factor 21 (FGF21) is an endocrine growth factor, a regulator of fatty acids and glucose metabolism. Recently, it has been reported that FGF21 expression is regulated by activating transcription factor 4 (ATF4), a transcription factor activated by various stimuli such as endoplasmic reticulum (ER) stress. ATF4 binds to the amino acid response element (AARE), a binding site for ATF4, in the promoter region of the target genes. The two response elements for ATF4 (AARE1 and AARE2) ...
7 CitationsSource
#1Yu Takahashi (UTokyo: University of Tokyo)H-Index: 13
#2Akihiro Shinoda (UTokyo: University of Tokyo)H-Index: 4
Last.Ryuichiro Sato (UTokyo: University of Tokyo)H-Index: 37
view all 6 authors...
Perilipin2 (Plin2), also known as adipose differentiation-related protein (ADRP), or adipophilin, is a member of the PAT family involved in lipid droplet (LD) formation in the liver and peripheral tissues. Although Plin2 was originally identified as a highly expressed gene in adipocytes, its physiological role in mature adipocytes is largely unknown. In this report, we investigated the regulation of Plin2 expression and its function in differentiated adipocytes of mouse embryonic fibroblasts (ME...
30 CitationsSource
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