Original paper
AIF-independent parthanatos in the pathogenesis of dry age-related macular degeneration
Abstract
Cell death of retinal pigment epithelium (RPE) is characterized as an essential late-stage phenomenon of dry age-related macular degeneration (AMD). The aim of this study was to elucidate the molecular mechanism underlying RPE cell death after exposure to oxidative stress, which occurs often because of the anatomical location of RPE cells. ARPE-19, an established RPE cell line, exhibited necrotic features involving poly (ADP-ribose) polymerase-1...
Paper Details
Title
AIF-independent parthanatos in the pathogenesis of dry age-related macular degeneration
Published Date
Jan 5, 2017
Journal
Volume
8
Issue
1
Pages
e2526 - e2526
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Notes
History