Abstract 3850: Understanding PARP inhibitor sensitivity: Analyses of the genetic interactions between specific PARP inhibitor targets and DNA double-strand repair pathways

Poly (ADP-ribosyl)ation (PARylation) of histones and DNA repair factors is necessary to maintain genomic integrity in mammalian cells. In response to DNA damage, PARylation is primarily catalyzed by two Poly (ADP-ribose) polymerases (PARPs), PARP1 and PARP2. Ablation of PARP1 in the mouse results in embryonic lethality when combined with deficiencies for the DNA repair factors that mediate homologous recombination (HR; such as ATM or H2AX) or...