Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase
Abstract
The allosteric inhibitors of integrase (termed ALLINIs) interfere with HIV replication by binding to the viral-encoded integrase (IN) protein. Surprisingly, ALLINIs interfere not with DNA integration but with viral particle assembly late during HIV replication. To investigate the ALLINI inhibitory mechanism, we crystallized full-length HIV-1 IN bound to the ALLINI GSK1264 and determined the structure of the complex at 4.4 Å resolution. The...
Paper Details
Title
Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase
Published Date
Dec 9, 2016
Journal
Volume
14
Issue
12
Pages
e1002584 - e1002584
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