Original paper

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

Volume: 30, Issue: 6, Pages: 909 - 924
Published: Dec 1, 2016
Abstract
Chronic jet lag induces spontaneous hepatocellular carcinoma (HCC) in wild-type mice following a mechanism very similar to that observed in obese humans. The process initiates with non-alcoholic fatty liver disease (NAFLD) that progresses to steatohepatitis and fibrosis before HCC detection. This pathophysiological pathway is driven by jet-lag-induced genome-wide gene deregulation and global liver metabolic dysfunction, with nuclear...
Paper Details
Title
Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis
Published Date
Dec 1, 2016
Volume
30
Issue
6
Pages
909 - 924
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