Review paper
CRISPR–Cas9 Structures and Mechanisms
Abstract
Many bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated (Cas) systems employ the dual RNA–guided DNA endonuclease Cas9 to defend against invading phages and conjugative plasmids by introducing site-specific double-stranded breaks in target DNA. Target recognition strictly requires the presence of a short protospacer adjacent motif (PAM) flanking the target site, and subsequent R-loop formation and...
Paper Details
Title
CRISPR–Cas9 Structures and Mechanisms
Published Date
May 22, 2017
Journal
Volume
46
Issue
1
Pages
505 - 529
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