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Annual Review of Biophysics
IF
12.18
Papers
288
Papers 289
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Newest
#1Felix Wong (MIT: Massachusetts Institute of Technology)H-Index: 7
#1Felix Wong (MIT: Massachusetts Institute of Technology)H-Index: 1
Last. Jeremy Gunawardena (Harvard University)H-Index: 30
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Determining whether and how a gene is transcribed are two of the central processes of life. The conceptual basis for understanding such gene regulation arose from pioneering biophysical studies in eubacteria. However, eukaryotic genomes exhibit vastly greater complexity, which raises questions not addressed by this bacterial paradigm. First, how is information integrated from many widely separated binding sites to determine how a gene is transcribed? Second, does the presence of multiple energy-...
2 CitationsSource
#1Xiaona Fang (SBU: Stony Brook University)
#2Jin Wang (SBU: Stony Brook University)
We discuss new developments in the nonequilibrium dynamics and thermodynamics of living systems, giving a few examples to demonstrate the importance of nonequilibrium thermodynamics for understanding biological dynamics and functions. We study single-molecule enzyme dynamics, in which the nonequilibrium thermodynamic and dynamic driving forces of chemical potential and flux are crucial for the emergence of non-Michaelis-Menten kinetics. We explore single-gene expression dynamics, in which nonequ...
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#1Vickery L. Arcus (University of Waikato)H-Index: 32
#2Adrian J. Mulholland (UoB: University of Bristol)H-Index: 43
We review the adaptations of enzyme activity to different temperatures. Psychrophilic (cold-adapted) enzymes show significantly different activation parameters (lower activation enthalpies and entr...
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#1Jeong-Mo Choi (KAIST)H-Index: 11
#2Alex S. Holehouse (WashU: Washington University in St. Louis)H-Index: 19
Last. Rohit V. Pappu (WashU: Washington University in St. Louis)H-Index: 48
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Many biomolecular condensates appear to form via spontaneous or driven processes that have the hallmarks of intracellular phase transitions. This suggests that a common underlying physical framewor...
16 CitationsSource
Abstract The FtsZ protein is a highly conserved bacterial tubulin homolog. In vivo, the functional form of FtsZ is the polymeric, ring-like structure (Z-ring) assembled at the future division site ...
1 CitationsSource
Abstract The fundamental process of adaptive immunity relies on the differentiation of self from nonself. Nucleated cells are continuously monitored by effector cells of the immune system, which po...
2 CitationsSource
#1Ron Elber (University of Texas at Austin)H-Index: 47
Recent advances in theory and algorithms for atomically detailed simulations open the way to the study of the kinetics of a wide range of molecular processes in biophysics. The theories propose a shift from the traditionally very long molecular dynamic trajectories, which are exact but may not be efficient in the study of kinetics, to the use of a large number of short trajectories. The short trajectories exploit a mapping to a mesh in coarse space and allow for efficient calculations of kinetic...
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#1Stefan Jakobs (MPG: Max Planck Society)H-Index: 57
#2Till Stephan (MPG: Max Planck Society)H-Index: 3
Last. Christian Brüser (MPG: Max Planck Society)H-Index: 3
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Mitochondria are essential for eukaryotic life. These double-membrane organelles often form highly dynamic tubular networks interacting with many cellular structures. Their highly convoluted contig...
2 CitationsSource
#1Paul Campitelli (ASU: Arizona State University)H-Index: 2
#2Tushar Modi (ASU: Arizona State University)H-Index: 2
Last. S. Banu Ozkan (ASU: Arizona State University)H-Index: 21
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Advances in sequencing techniques and statistical methods have made it possible not only to predict sequences of ancestral proteins but also to identify thousands of mutations in the human exome, s...
2 CitationsSource
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